黑素瘤细胞黏附分子在慢性阻塞性肺疾病中的表达及意义

Expression and significance of MCAM in patients with chroinc obstructive pulmonary disease

目的比较慢性阻塞性肺疾病(COPD)稳定期、急性加重期和健康人群黑素瘤细胞黏附分子(MCAM)含量。方法选取COPD稳定期患者30例,COPD急性加重期患者30例及无COPD疾病的健康体检者(对照组)30例,并通过流式细胞仪检测3组MCAM的含量。结果 COPD稳定期患者的MCAM含量显著高于对照组,COPD急性加重期患者的MCAM含量明显高于COPD稳定期患者及对照组(P<0.05)。结论 COPD急性加重期内皮损伤主要在毛细血管,甚至持续至临床症状消失之后,高水平MCAM提示肺部炎症的存在,预示COPD患者容易急性加重。

Objective To compare MCAM number in stable COPD patients,acute COPD and normal control. Methods MCAM numbers were examined in 30 stable COPD patients,30 patients with acute COPD and 30 healthy non-COPD volunteers （control group）by flow cytometry. Results MCAM number in stable COPD patients was significantly higher than that in control group,MCAM number in patients with acute COPD was significantly higher than that in stable COPD patients and control group respectively （P〈0.05）. Conclusion Endothelial damage during acute exacerbation of COPD is mainly pulmonary capillary,even continue to the clinical symptoms disappeared.Higher MCAM level suggest the presence of lung inflammation,indicate COPD patients who are susceptible to exacerbation.