C反应蛋白定性检测在良恶性胸腹水鉴别诊断中的临床意义

Clinical Value of Qualitative Determination of C-Reactive Protein in the Differential Diagnosis of Benign and Malignant Pleural Effusions or Ascites

目的:探讨C反应蛋白(C-reactive protein,CRP)定性检测在良恶性胸腹水鉴别诊断中的临床价值。方法:采用胶乳凝集法定性检测3820例患者胸腹水中的CRP,在反应板孔中先后加入标本及胶乳试剂,充分混匀,2 min后观察结果。如肉眼可见凝集颗粒,则为阳性。结果:672例恶性胸腹水标本中CRP阳性率为6.1%,其中32例淋巴造血系统肿瘤患者的胸腹水中CRP阳性率为75.0%,640例上皮性恶性肿瘤患者胸腹水中CRP阳性率为2.7%;3148例良性胸腹水中CRP阳性率为21.8%。良性胸腹水CRP阳性率显著高于恶性胸腹水,淋巴造血系统肿瘤胸腹水CRP阳性率显著高于上皮性恶性肿瘤胸腹水(P<0.01)。结论:CRP定性检测对于鉴别良恶性胸腹水以及鉴别淋巴造血系统肿瘤与上皮性恶性肿瘤胸腹水有一定价值。

Objective：To explore the clinical value of qualitative determination of C-reactive protein （CRP） in the differential diagnosis of benign and malignant pleural effusions or ascites .Methods ：CRP in 3820 cases of pleural effusions and ascites were qualitatively examined by latex agglutination method .Specimen and latex reagent were added to the wells of the reaction plate successively .The result was observed after 2 minutes’ thorough mixing .The result was judged as positive if agglutination par-ticles were visible .Results：The positive rate of CRP in 672 cases of malignant pleural effusions and ascites was 6 .1% .The positive rate of CRP in pleural effusions and ascites was 75 .0% in 32 cases of hematopoietic and lymphoid tissue tumors ,and 2 .7% in 640 cases of epithelial malignant tumors .The positive rate of CRP in pleural effusions and ascites in 3148 cases of be-nign diseases was 21 .8% .The positive rate of CRP in benign pleural effusions and ascites was higher than that in malignant pleural effusions and ascites（P〈0 .05） .The positive rate of CRP in pleural effusions and ascites of patients with hematopoietic and lymphoid tumors was higher than that of patients with epithelial malignant tumors .Conclusions ：Qualitative determination of CRP in pleural effusions and ascites can be used to differentiate benign and malignant pleural effusions and ascites ,and to differentiate pleural effusions and ascites of hematopoietic and lymphoid tissue tumors and epithelial malignant tumors .