结肠癌患者血清抵抗素和瘦素水平的检测及其临床意义

Detection of Serum Levels of Resistin and Leptin in Patients with Colon Cancer and Its Clinical Significance

目的:研究结肠癌患者血清抵抗素和瘦素水平与结肠癌临床病理特征的关系。方法:选择2013年3月—12月接受根治性手术治疗的29例结肠癌患者为研究组,另选27例健康志愿者为对照组,采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测研究组和对照组血清抵抗素和瘦素水平,分析结肠癌患者血清抵抗素和瘦素水平与其临床病理特征的关系。结果:研究组血清抵抗素和瘦素水平与对照组比较差异均有统计学意义(P<0.05)。不同分期或不同分化程度的结肠癌患者间血清抵抗素和瘦素水平差异无统计学意义(P>0.05)。结论:抵抗素和瘦素可能与结肠癌的发生发展有一定关系。

Objective：To investigate the correlation between serum levels of resistin and leptin in patients with colon cancer and clinicopathological characteristics of colon cancer .Methods ：A total of 29 patients who underwent radical surgical resection for colon cancer from Mar 2013 to Dec 2013 were selected as the study group ,while 27 healthy volunteers were selected as the con-trol group .The serum levels of resistin and leptin were measured by enzyme-linked immunosorbent assay（ELISA） .The correla-tion between patients′ serum levels of resistin and leptin and their clinicopathological characteristics were analyzed .Results：The serum levels of resistin and leptin in the study group were significantly different from those in the control group （P〈0 . 05） .The serum levels of resistin and leptin had no significant difference among patients with colon cancer at different stages or different differentiation degrees（P〉0 .05） .Conclusions ：Resistin and leptin may be involved in the occurrence and development of colon cancer .