2型糖尿病视网膜病变的相关危险因素分析

Analysis on Risk Factors Related to Retinopathy in Type 2 Diabetes Mellitus

目的:探讨2型糖尿病视网膜病变(diabetic retinopathy,DR)的相关危险因素。方法:选择2012年10月—2013年8月行眼底检查的糖尿病患者253例,采用Logistic回归分析DR的相关危险因素。结果:253例糖尿病患者中,DR患者77例(30.43%),DR组与非DR组相比,年龄、病程、收缩压(systolic blood pressure,SBP)、尿微量白蛋白(urine microalbumin,U-MA)、UMA与尿肌酐(urine creatinine,UCr)比值的差异均有统计学意义(P<0.05)。Logistic回归分析显示,糖尿病病程是DR的独立危险因素(OR=1.191,P<0.005)。77例DR患者中,单纯DR患者65例,增殖期DR患者12例,两组总胆固醇(total cholesterol,TC)、U-MA、U-MA/UCr差异均有统计学意义(P<0.05)。结论:DR与年龄、病程、SBP、U-MA、U-MA/UCr等因素有关,糖尿病病程是DR的独立危险因素。

Objective： To explore the risk factors related to diabetic retinopathy （DR） in type 2 diabetic mellitus patients. Methods：From October 2012 to August 2013, 253 patients with type 2 diabetic mellitus were examined by fundoscopy. Logistic regression analysis was used to evaluate the related risk factors to DR. Results： There were 77 patients （30.43%） with DR in 253 DM patients. The differences of age, diabetic duration, systolic blood pressure （SBP）, urine microalbumin （U-MA）, and the ratio of U-MA to urine creatinine （UCr） were statistically significant between DR group and non-DR group （P〈0.05）. Logistic regression analysis showed that diabetic duration was an independent risk factor related to DR （OR = 1.191, P〈0.005）. There were 65 patients with non-proliferative DR and 12 patients with proliferative DR. The above groups had statisti- cally different total cholesterol （TC）, U-MA and U-MA/UCr （P〈0.05）. Conclusions： DR is correlated to age, diabetic dura- tion, SBP, U-MA and U-MA/UCr, in which diabetic duration is an independent risk factor related to DR.