缺乏形态学分化非小细胞性肺癌的免疫组化分型

Immunohistochemical Type on Lack of Morphological Differentiation of Non-small Cell Lung Cancer

目的:探讨免疫组化在缺乏形态学分化的非小细胞性肺癌病理分型中的作用。方法:用一组6种抗体和免疫组化EnVision二步法对40例缺乏形态学分化的非小细胞性肺癌者进行检测。结果:本组鳞状细胞癌12例,腺癌23例,神经内分泌癌5例。本组CK7(62.5%)和甲状腺转录因子-1(55.0%)表达阳性率最高。结论:缺乏形态学分化的非小细胞性肺癌大多为腺癌,用6种抗体组成套餐的免疫组化检测能提高肺癌病理分型的诊断准确率。

Objective： To investigate the role of immunohistochemistry in pathological type of the lack of morphological differentiation of non-small cell lung cancer. Methods. A set of six kinds of antibodies and immunohistochemical EnVision two step method were used to detect lack of morphological differentiation of 40 cases with non-small cell lung cancer. Results： The highest positive rates of expression of CK7 and tyroid transfer factor- 1 in this study （12 cases of squamous cell carcinoma, 23 cases of adenocarcinoma and 5 cases ofneuroendocrine carcinoma）were 62.5% and 55.0%. Conclusion： The lack of morphological differentiation of non-small cell lung cancer is mostly for adenocarcinoma. The immunohistochemical detection of antibodies in six antibodies package can improve pathological type of lung cancer diagnostic accuracy.