肥胖与腔隙性脑梗死后轻度认知障碍的相关性研究

Correlation study on mild cognitive impairment after lacunar infarction and obesity

目的:探讨腹型肥胖和体重指数界定肥胖是否同为腔隙性脑梗死后轻度认知障碍的危险因素。方法:收集腔隙性脑梗死患者149例,进行蒙特利尔认知评估量表评分,采集病史、人口学资料,记录腰围、身高、体重及血管危险因素,行神经系统体检。根据认知能力将患者分为两组:轻度认知功能障碍者为病例组,认知正常者为对照组。采用非条件Logistic回归分析,最终明确两种不同类型肥胖是否同为腔隙性脑梗死后轻度认知障碍的危险因素。结果:病例组腹型肥胖率(79.5%)高于对照组(48.7%),差异有统计学意义(χ2=11.624,P=0.001);而两组间体重指数界定的肥胖率(分别为20.5%、10.5%)差异无统计学意义(P>0.05)。结论:腹型肥胖是腔隙性脑梗死后轻度认知障碍的危险因素,体重指数界定的肥胖不增加腔隙性脑梗死后轻度认知障碍的风险。

Objective： To investigate if the different strains of obesity（ abdominal obesity and that defined by BMI） are risk factors for mild cognitive impairment due to lacunar infarction. Methods： One hundred forty-nine lacunar infarction cases were detailed,graded according Montreal cognitive assessment,and collected past and present history,demographic data,waist circumference,height,weight,vascular risk factors and neurological examination. These cases were divide into two groups. One was case group with mild cognitive impairment after lacunar infarct while the other was control group with normal cognition. It was used by non conditional Logistic regression analysis. Finally wheather two different types of obesity were risk factors for mild cognitive impairment after lacunar infarction was confirmed. Results： Proportions of abdominal obesity（ 79. 5%） were higher in the case group than in the control group（ 48. 7%）,it was statistically significant（ χ2= 11. 624,P = 0. 001）. There was no difference in terms of obesity defined by BMI between the two groups（ 20. 5% vs 10. 5%）. Conclusions： The abdominal obesity is a risk factor for mild cognitive impairment after lacunar infarct. Obesity defined by BMI does not increase the risk of mild cognitive impairment after lacunar infarct.