摘要
Recent studies show that long non-coding RNAs(lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.
Recent studies show that long non-coding RNAs （lncRNAs） play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.
基金
the Longhua Medical Project of State Clinical Research Center of TCM in Longhua Hospital(Nos.LYTD-21 and JDZX2012123)
the National Basic Research Program(973) of China(No.2013CB967402)
the National Natural Science Foundation of China(Nos.91019004 and 91229123)
