CK17在宫颈不成熟鳞状化生及宫颈上皮内瘤变中的表达及意义

Expression of CK17 and their significance in cervical squamous immature metaplasia and cervical intraepithelial neoplasia

宫颈癌是目前仅次于乳腺癌的女性最常见的恶性肿瘤,中国每年约有近13万新发病例,约占全世界新发病例总数的1/5,且出现年轻化趋势。众所周知,宫颈病变的发展是一个逐渐的缓慢的演变过程,从宫颈上皮不成熟化生(IM)到宫颈上皮内瘤变(CIN)是发展为宫颈浸润癌的关键过程,但并非所有的宫颈病变均发展为癌,部分可有消退或逆转的可能。病理诊断中由于IM和CIN在常规HE切片中有相似之处,受观察者主客观因素的影响,有时单纯依靠病理形态学鉴别存在一定的困难,然而这两种病变的预后和治疗方法相差甚远。因此早期诊断CIN并确定其预后转归是发现早期宫颈癌和减少宫颈癌发生的关键。细胞角蛋白17(CK17)是近年来与宫颈病变研究较多的因素,是宫颈储备细胞的标志物,随着宫颈病变的发展,CK17的表达可出现一定的变化,研究其在不同宫颈病变组织中的表达可作为预测宫颈癌高危患者的指标。

Cervical cancer is the second to breast cancer of women in the most common malignant tumors. Every year there are nearly 130,000 new cases in China, nearly 1/5 of the total number of new cases in the world. The patients is becoming younger and younger. As is known to all, the development of cervical lesions has a slow evolution, from the cervical epithelial metaplasia immature （IM） to cervical intraepithelial neoplasia （CIN）. This is the key process to the development of cervical carcinoma invading, but not all of the cervical lesions will be cancer, the part can be faded or reverse. Because IM and CIN in pathological diagnosis in routine HE slices are similar, from the subjective and objective factors. Sometimes it is difficult for observes to identify the pathological morphology alone. However, this two lesions are different in the prognosis and treatment. So diagnosis of CIN and determine in early stage cervical cancer and its prognostic outcome is crucial for decreasing the occurrence of cervical cancer. Cytakeratin 17 （CK17） is a marker for cervical reserve cells reflecting a cell metaplasia from immature to mature phenomenon, of CK17 With the development of cervical lesions ,the expression of CK17 has some changes. Therefor, the reseach of the expression of CK17 in different cervical lesions can be used as a prediction index of patients at high risk of cervical cancer.