期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

炎症因子IL-1β、IL-8、TNF-α与乳腺癌的关系 被引量：5

Inflammatory cytokines IL- 1 beta,IL- 8,the relationship between the TNF alpha and breast cancer
下载PDF
导出
摘要 研究发现炎症在肿瘤的生长与增殖中发挥着重要的作用,特别是炎症因子IL-1β、IL-8、TNF-α与肿瘤的发生、发展关系更为密切。炎症因子IL-1β、IL-8、TNF-α可通过改变肿瘤细胞的生存微环境,促进肿瘤新生血管生成,从而促进肿瘤细胞生长与增殖,同时也促进了肿瘤的转移,因此研究炎症因子(IL-1β、IL-8、TNF-α)与乳腺癌的关系具有重要意义。 Study has found that inflammation play an important role in the growth and proliferation of tumor, especially the inflammatory eytokines IL - 1 beta, IL - 8 and TNF alpha having a closer relationship with the occurrence and development of tumor. The three of inflammatory factors promote angiogenesis, thua promoting the growth and proliferation of tumor cells, and also promoted tumor metastasis. Therefore, it has an important significance to study the relationship between inflammatory factors （ IL - 1β, IL - 8 and TNF - α） and breast cancer.
作者 景彩萍 何静子 魏晓丽
机构地区 延安大学医学院 延安市人民医院
出处 《延安大学学报（医学科学版）》 2014年第3期61-63,共3页 Journal of Yan'an University:Medical Science Edition
基金 陕西省教育厅专项科研计划项(NO2010Jkg10) 延安大学科研计划项目(YDK2010-09)
关键词 炎症因子IL-1β IL-8 TNF-Α 乳腺癌 Inflammatory cytokines IL - 1 beta IL - 8 TNF alpha Breast cancer
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1Hussain,S.P.et a 1.Inflammation and cancer:an ancient rink with novdl potentials[J].Int.J.Cancer 2007,121,2373-2380.
  • 2Pantsechenko AG,Pushkarl,Anderson KH,et al.The interleuKin-1 family of cytokines and receptor in human breast cancer:Implications of tumor progression[J].Int J Oncol,2003,23:269-284.
  • 3Warren MA,Shoemaker SF,Shealy DJ,et al.Tumor necrosis factor deficiency inhibits mammary tumor genesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice[J].Mol Cancer Ther,2009,8 (9):2655.
  • 4Apte RN.Krelin Y.Song X,et al.Effects of micro-environment-and malignant cell-derived interleukin-1 in carci-nogenesis,tumnour invasiveness and tumour-host interactions[J].Eur J Cancer,2006,42(6):751-759.
  • 5Caine GJ,Lip GY,Stonelake PS,et al.Platelet activation,coagulation and angiogenesis in breast and prostate carcinoma[J].Thromb Haemost,2004,92(1):185-190.
  • 6Lin Y,Huang R,Chen L,et al.Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays[J].Int J Cancer,2004,109 (4):507-515.
  • 7Wu WS.The signaling mechanism of ROS in tumor progression[J].Cancer Metastasis Rev 2006 ;25:695-705.
  • 8Azad N,Rojanasakal Y,Vallyathan V.Inflammation and lung cancer:roles of reactive oxygen/nitrogen species[J].J Toxicol Environ Health B Cdt Rev 2008 ;Ⅱ:1-15.
  • 9Berry K K,Varney M L,Dave B J,et al.Expression of interleuk in 8 in human metastatic endometrial carcinma cells and its regulation by inflammatory cyinkines[J].Int J Gynecnl Cancer 2001,11:54-60.
  • 10Soria G,Ofri-Shahak M,Haas I,et al.Inflammatory mediators in breast cancer:Coordinated expression of TNF-α & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition[J].BMC Cancer,2011,11(130):1471-91.

二级参考文献9

  • 1Tu W,Zhang DK,Cheung PT,et al.Effect of insulin-like growth factor 1 on PHA-stimulated cord blood mononuclear cell telomerase activity[J].Br J Haematol,1999,104 (4):785-794.
  • 2Bermont L,Lamielle F,Fauconnet S,et al.Regulation of vascular endothelial growth factor expression by insulin-like growth factor-I in endometrial adenocarcinoma cells[J].Int J Cancer,2000,85(1):117-123.
  • 3Dunn SE,Torres JV,Oh JS,et al.Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase[J].Cancer Res,2001,61(4):1 367-1 374.
  • 4Wu Y,Cui K,Miyoshi K,et al.Reduced circulating insulin-like growth factor-I levels delay the onset of chemically and genetically induced mammary tumors[J].Cancer Res,2003,63(15):4 384-4 388.
  • 5Muti P,Quattrin T,Grant BJ,et al.Fasting glucose is a risk factor for breast cancer:a prospective study[J].Cancer Epidemiol Biomarkers Prev,2002,11(11):1 361-1 368.
  • 6Petridou E,Papadiamantis Y,Markopoulos C,et al.Leptin and insulin growth factor-I in relation to breast cancer[J].Cancer Causes Control,2000,11(5):383-388.
  • 7Laban C,Bustin SA,Jenkins PJ.The GH-IGF-I axis and breast cancer[J].Trends Endocrinol Metab,2003,14:28-34.
  • 8Misawa A,Hosoi H,Arimoto A,et al.N-Myc induction stimulated by insulin-like growth factor I through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells[J].Cancer Res,2000,60(1):64-69.
  • 9廖清华,黄任贵,陆云飞,林坚,曾健,黄源,张诗峰.生长激素受体和生长抑素受体2、3、5在人乳腺癌组织中的表达及相关性研究[J].广西医科大学学报,2008,25(4):553-555. 被引量：2

共引文献5

同被引文献83

  • 1万行军,易正辉,方贻儒,洪武,吴志国,汪栋祥,张晨,胡莺燕,陈俊,苑成梅,禹顺英.汉族人群NTRK2基因多态性与精神分裂症关联研究[J].上海精神医学,2008,20(2):72-74. 被引量：3
  • 2Inoue J I, Gohda J, Akiyama T, et al. NF-kappa B activation in development and progression of cancer[J]. Cancer Sci, 2007, 98(3): 268.
  • 3Karin M. Nuclear factor-kappaB in cancer developmentnd progression[J]. Nature, 2006, 441(792): 431.
  • 4Baldwin A S. Series introduction: the transcription factor NF- kappaB and human disease[J]. J Clin Invest, 2001, 107(1): 3.
  • 5O'dea E, Hoffmann A. The regulatory logic of the NF-kappaB signaling system[J]. Cold Spring Harb Perspeet Biol, 2010, 2(1): a000216.
  • 6Oeckinghaus A, Ghosh S. The NF-kappa B family of transcription factors and its regulation [J]. Cold Spring Harb Perspect Biol, 2009, 1(4): a000034.
  • 7Karin M, Greten F R. NF-kappaB: linking inflammation and immunity to cancer development and progression[J]. Nat Rev Immunol, 2005, 5(10): 749.
  • 8Luo J L, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing Life and death-a new approach to cancer therapy[J]. J Clin Invest, 2005, 115(10): 2625.
  • 9Kaisho T, Takeda K, Tsujimura T, et al. IkappaB kinase alpha is essential for mature B cell development and function[J]. J Exp Med, 2001, 193(4): 417.
  • 10Pahl H L. Activators and target genes of Rel/NF-kappaB transcription factors[J]. Oncogene, 1999, 18(49): 6853.

引证文献5

二级引证文献26

延安大学学报（医学科学版）
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部