期刊文献+

利拉鲁肽治疗2型糖尿病的疗效与安全性综合评价 被引量:2

Efficacy and safety of liraglutide treatment in patients with type 2 diabetes mellitus
下载PDF
导出
摘要 很多传统降糖药在控制血糖同时需要付出体重增加、低血糖风险增高等代价,并继而增高心血管事件风险。新型降糖药人GLP-1类似物利拉鲁肽通过达到血浆药理学浓度的GLP-1升高,可达到降低血糖的作用,并因其可能具有血管保护效应而引起人们关注。本文通过对利拉鲁肽单药治疗或与其他降糖药物联合治疗的疗效和安全性进行综合性评价。
作者 窦京涛
出处 《药品评价》 CAS 2014年第15期48-52,共5页 Drug Evaluation
  • 相关文献

参考文献20

  • 1Garber A, Henry R, Ramer R, et al. Liraglufide versus glimepiride monotherapy for type 2 diabetes(LEAD-3 Mono): a randomised, 52-week, phase m, double- blind, parallel-treatment trial[J]. Lancet, 2009, 373(9662): 473-481.
  • 2Garber A, Henry RR, Ramer R, et al. Liraglufide, a once-daily human glucagon- like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monothempy compared with glimepiride in patients with type 2 diabetes[J]. Diabetes Obes Metab, 2011, 13(4): 348-356.
  • 3Mane M, Shaw J, Brandle M, et al. Liralutide a once-daily htanan GLP- 1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes(LEAD-1 SU)[J]. Diabet Mad, 2009, 26(3): 268- 278.
  • 4Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD(liraglutide effect and action in diabetes)-2 study[l]. Diabetes Care, 2009, 32(1 ): 84-90.
  • 5Nauck M, Frid A, Hermansen K, et al. Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year resdts from the LEAD-2 study[J]. Diabetes Obes Metab, 2013, 15(3): 204-212.
  • 6Yang W, Chen L, Ji Q, et al. Liraglutide provides similar glycaemic eonlrol as glimepiride(both in combination with mefformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a 16-week, randomized, double-blind, active control Irial(*)[J]. Diabetes Obes Metab, 2011, 13(1): 81-88.
  • 7Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliplin for patients with type 2 diabetes who did not have adequate glyeaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial[J]. Lancet, 2010, 375(9724): 1447-1456.
  • 8Prafley R, Nauck M, Bailey T, et al. One year of liraglutide trealment offers sustained and more effective glycaemie control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial[J]. Int J Clin Pratt, 2011, 65(4): 397-407.
  • 9Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes(LEAD-4 Met+TZD)[J]. Diabetes Care, 2009, 32(7): 1224-1230.
  • 10Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus(LEAD-5 met+SU): a randomised controlled trial[J]. Diabetologia, 2009, 52(10): 2046-2055.

二级参考文献32

  • 1Gallwitz B.GLP-1 agonists and dipeptidyl-peptidase IV inhibitors.Handb Exp Pharmacol,2011,203:53-74.
  • 2Jahn E,Sausele T.Liraglutide:a human GLP-1 analogue for the treatment of diabetes mellitus type 2.Med Monatsschr Pharm,2009,32:402-407.
  • 3Rossi MC,Nicolucci A.Liraglutide in type 2 diabetes:from pharmacological development to clinical practice.Acta Biomed,2009,80:93-101.
  • 4Knudsen LB.Liraglutide:the therapeutic promise from animal models.Int J Clin Pract Suppl,2010,64:4-11.
  • 5Schmidt WE.Early clinical studies with liraglutide.Int J Clin Pract Suppl,2010,64:12-20.
  • 6Marre M,Shaw J,Brandle M,et al.Liraglutide,a once-daily human GLP-1 analogue,added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU).Diabet Med,2009,26:268-278.
  • 7Nauck M,Frid A,Hermansen K,et al.Efficacy and safety comparison of liraglutide,glimepiride,and placebo,all in combination with metformin,in type 2 diabetes:the LEAD (liraglutide effect and action in diabetes)-2 study.Diabetes Care,2009,32:84-90.
  • 8Garber A,Henry R,Ratner R,et al.Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono):a randomised,52-week,phase III,double-blind,parallel-treatment trial.Lancet,2009,373:473-481.
  • 9Zinman B,Gerich J,Buse JB,et al.Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).Diabetes Care,2009,32:1224-1230.
  • 10Russell-Jones D,Vaag A,Schmitz O,et al.Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU):a randomised controlled trial.Diabetologia,2009,52:2046-2055.

共引文献20

同被引文献21

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部