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MicroRNAs: the novel targets for Ebola drugs 被引量:2

MicroRNAs: the novel targets for Ebola drugs
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摘要 The re-emergence of Ebola viral disease (EVD) in West Africa has caused an international alarm, even panic. As of August 27th, 2014, the Ebola virus (EBOV) has infected 3069 people with 1552 death cases starting from December 2013 (http://www.who.int/csr/don/2014 08 28 ebola/en/). Recently, an outbreak of Ebola hemorrhagic fever in the north of Congo (Democratic Republic) has been confirmed besides Guinea, Liberia, Sierra Leone and Nigeria. So far the epidemic has not been effectively controlled. The re-emergence of Ebola viral disease(EVD)in West Africa has caused an international alarm,even panic.As of August 27th,2014,the Ebola virus(EBOV)has infected3069 people with 1552 death cases starting from December2013(http://www.who.int/csr/don/20140828ebola/en/).Recently,an outbreak of Ebola hemorrhagic fever in the north of Congo(Democratic Republic)has been
出处 《Science China(Life Sciences)》 SCIE CAS 2014年第10期985-986,共2页 中国科学(生命科学英文版)
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  • 1Zampieri CA, Sullivan NJ, Nabel GJ. Immunopathology of highly virulent pathogens: insights from Ebola virus. Nat Immunol, 2007, 8: 1159-1164.
  • 2Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ. Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat Med, 2000, 6: 886-889.
  • 3Sheng MM, Zhong Y, Chen Y, Du JC, Ju XW,Zhao C, Zhang GG, Zhang LF, Liu KT, Yang N, Xie P, Li DS, Zhang MQ, JIANG CY. Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. Sci China Life Sci, 2014 (in press).
  • 4Enserink M. Infectious diseases. Ebola drugs still stuck in lab. Science, 2014, 345: 364-365.

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