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Fighting Ebola with ZMapp: spotlight on plant-made antibody 被引量:3

Fighting Ebola with ZMapp: spotlight on plant-made antibody
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摘要 Currently,a large Ebola endemic is ongoing in West Africa.According to the World Health Organization,as of August19,the viral outbreak has led to 2240 suspected and confirmed cases and 1229 deaths in four countries:Guinea,Liberia,Nigeria,and Sierra Leone(http://www.cdc.gov/vhf/ebola/outbreaks/guinea/index.html). Currently, a large Ebola endemic is ongoing in West Africa. According to the World Health Organization, as of August 19, the viral outbreak has led to 2240 suspected and con- firmed cases and 1229 deaths in four countries: Guinea, Liberia, Nigeria, and Sierra Leone (http://www.cdc.gov/vhf/ ebola/outbreaks/guinea/index.html).
出处 《Science China(Life Sciences)》 SCIE CAS 2014年第10期987-988,共2页 中国科学(生命科学英文版)
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  • 1Hiatt A, Cafferkey R, Bowdish K. Production of antibodies in transgenic plants. Nature, 1989, 342: 76-78.
  • 2Giritch A, Marillonnet S, Engler C, van Eldik G, Botterman J, Klimyuk V, Gleba Y. Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors. Proc Natl Acad Sci USA, 2006, 103: 14701-14706.
  • 3Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, Mason HS, Chen Q. High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol Bioeng, 2010, 106: 9-17.
  • 4Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ, Olinger GG. Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant. Proc Natl Acad Sci USA, 2011, 108: 20690-20694.
  • 5Olinger GG Jr., Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L, Zeitlin L. Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques. Proc Natl Acad Sci USA, 2012, 109: 18030-18035.

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