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CD40配体及其应用的研究进展 被引量：2

Research progress on CD40 ligand and its application
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摘要 CD40配体是肿瘤坏死因子超家族中的一员,主要活化T细胞表面的共刺激分子,特别是CD4＋T细胞.CD40配体通过与其受体CD40的相互作用,在诱导机体产生免疫应答中起重要作用.此文就CD40L配体的结构和功能以及在病毒DNA疫苗和肿瘤治疗中的应用作一综述. CD40 ligand （CD40L）,a member of the tumor necrosis factor superfamily,mainly activates costimulatory molecules on T cell surface,especially CD4＋ T cells.CD40L plays an important role in immune response in human through the interaction between CD40L and its receptor CD40.This paper discusses the structure and function of CD40L and its application in viral DNA vaccine and tumor therapy.
作者 胡如西 洪艳
机构地区 浙江省医学科学院生物工程研究所
出处 《国际生物制品学杂志》 CAS 2014年第5期244-247,共4页 International Journal of Biologicals
基金 浙江省自然科学基金（LY12H19009） 浙江省科技计划项目（2011F20015）
关键词 CD40配体 佐剂 免疫 疫苗 DNA 肿瘤 治疗应用 CD40 ligand Adjuvants,immunologic Vaccines,DNA Neoplasms Therapeutic uses
分类号 R392 [医药卫生—免疫学]
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  • 1Wu RF,Dai M,Qiao YL,et al.Human papillomavirus infection in women in Shenzhen city,people's Republic of China,a population typical of recent Chinese urbanization[J].Int J Cancer,2007,121 (6):1306-1311.
  • 2Munoz N,Bosch FX,de Sanjose S,et al.Epidemiologic classification of human papillomavirus types associated with cervical cancer[J].N Engl J Med,2003,348(6):518-527.
  • 3Kamangar F,Qiao YL,Schiller JT,et al.Human papillomavirus serology and the risk of esophageal and gastric cancers:results from a cohort in a high-risk region in China[J].Int J Cancer,2006,119(3):579-584.
  • 4Wu Y,Chen Y,Li L,et al.Associations of high-risk HPV types and viral load with cervical cancer in China[J].J Clin Virol,2006,35(3):264-269.
  • 5Gomez-Gutierrez JG,Elpek KG,Montes de Oca-Luna R,et al.Vaccination with an adenoviral vector expressing calreti-culin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumor in mice[J].Cancer Immunol Immunother,2007,56(7):997-1007.
  • 6Kang TH,Lee JH,Bae HC,et al.Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments[J].Immunol Lett,2006,106(2):126-134.
  • 7Motoyama S,Ladines-Llave CA,Luis Villanueva S,et al.The role of human papillomavirus in the molecular biology of cervical carcinogenesis[J].Kobe J Med Sci,2004,50 (1-2):9-19.
  • 8Shi W,Bu P,Liu J,et al.Human papillomavirus type 16 E7 DNA vaccine:mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity[J].J Virol,1999,73(9):7877-7881.
  • 9Smahel M,Sima P,Ludvikova V,et al.Modified HPV16 E7 genes as DNA vaccine against E7-containing oncogenic cells[J].Virology,2001,281(2):231-238.
  • 10Firzlaff JM,Galloway DA,Eisenman RN,et al.The E7 protein of human papillomavirus type 16 is phosphorylated by casein kinase Ⅱ[J].New Biol,1989,1(1):44-53.

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国际生物制品学杂志
2014年 第5期

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