乳腺专用伽马成像在乳腺癌诊断中的意义

Clinical significance of breast-specific gamma imaging in diagnosis of breast cancer

目的探讨乳腺专用伽马成像(BSGI)在乳腺癌诊断中的意义。方法对2012年3月至2013年12月本院收治的136例体格检查发现或偶然发现乳腺肿块、拟行手术的女性患者进行前瞻性研究,检测BSGI高低浓聚值比,并将BSGI结果与病理结果进行对比。采用Mann-Whitney U非参数检验分析良、恶性肿瘤之间BSGI高低浓聚值比的差异。结果 BSGI诊断乳腺癌的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为95.1%(97/102)、73.5%(25/34)、89.7%(122/136)、91.5%(97/106)、83.3%(25/30)。乳腺癌的BSGI高低浓聚值比明显高于良性肿瘤(2.98±1.29比0.95±1.11,Z=-7.125,P=0.000)。结论 BSGI对于乳腺癌的诊断具有很好的临床应用价值。

Objective To evaluate the clinical significance of breast-specific gamma imaging （ BSGI） in diagnosis of breast cancer .Methods We performed a perspective study of 136 patients with indeterminate breast lesions who underwent dual-phase BSGI in our hospital from March 2012 to December 2013 .All included lesions were confirmed by pathology .BSGI was evaluated based on the visual interpretation and dual -phase semi-quantitative indices of lesion to non-lesion （ L/N） ratio, which were compared with pathological results . Difference of L/N ratio of BSGI between benign and malignant breast lesions was analyzed by Mann -Whitney U nonparametric test.Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of BSGI in the diagnosis of breast cancer were 95.1%（ 97/102 ） , 73.5%（ 25/34 ） , 89.7%（122/136）, 91.5%（97/106） and 83.3%（25/30）, respectively.L/N ratio of BSGI in breast cancer was significantly higher than that of benign tumor （ 2.98 ±1.29 vs 0.95 ±1.11 , Z=-7.125 , P=0.000 ） . Conclusion BSGI has a significant clinical value in the diagnosis of breast cancer .