冠状动脉慢血流与血管炎性因子的关系

Relationship between coronary slow flow and vascular inflammatory factors

目的:探讨冠状动脉慢血流(CSF)与血管炎性因子的关系。方法:选择229例冠状动脉造影正常的在院患者为研究对象,根据冠状动脉造影TIMI血流及校正TIMI帧数计数,患者被分为心外膜冠状动脉无明显病变但存在冠状动脉血流缓慢的CSF组(102例),心外膜冠状动脉完全正常且血流正常的冠脉正常组(127例)。收集一般临床资料,检测血管炎性因子,并分析其与CSF的关系。结果:与冠脉正常组比较,CSF组高敏性C-反应蛋白[(1.41+0.72)mg/L比(2.82+0.58)mg/L]、白细胞介素-1[(0.18±0.05)μg/L比(0.26±0.06)μg/L]、白细胞介素-6[(0.363±0.016)ng/L比(0.465±0.015)ng/L]水平均明显升高(P均<0.05)。Logistic回归分析显示,血管炎性因子是冠状动脉慢血流发生的危险因素(OR=1.008,P=0.015)。结论:冠状动脉血流速度与血管炎性因子密切相关。

Objective：To explore the relationship between coronary slow flow （CSF） and vascular inflammatory fac-tors .Methods ：A total of 229 inpatients with normal coronary angiography （CAG） results were selected as research object .According to CAG TIMI flow and corrected TIMI frame count ,patients were divided into CSF group （n=102 ,no obvious lesion in epicardial coronary artery but coronary flow was slow ） and normal coronary group （n=127 ,completely normal epicardial coronary artery and blood flow ） .General clinical data were collected ,vascular inflammatory factors were measured and their relationship with CSF was analyzed .Results：Compared with normal coronary group ,there were significant rise in levels of high sensitive C reactive protein [ （1.41＋0.72 ） mg/L vs . （2.82＋0.58） mg/L] ,interleukin 1 [ （0.18 ± 0.05）μg/L vs .（0.26 ± 0.06）μg/L] and interleukin 6 [ （0.363 ± 0.016） ng/L vs .（0.465 ± 0.015） ng/L] in CSF group , P〈0.05 all .Logistic regression analysis indicated that vas-cular inflammatory factors were risk factor for CSF occurrence （OR= 1.008 , P= 0.015 ） .Conclusion：Coronary flow velocity is closely related to vascular inflammatory factors .