鼻敏康颗粒对肺气虚变应性鼻炎大鼠模型鼻黏膜中TLR2和TLR4表达的影响

The effects of Biminkang granules on expressions of TLR2 and TLR4 in nasal mucosas of allergic rhinitis rat models with deficiency of lung-qi

目的:观察鼻敏康颗粒对肺气虚型变应性鼻炎大鼠鼻黏膜中Toll样受体2(TLR2)和Toll样受体4(TLR4)表达的影响。方法:SD大鼠随机分为空白组、模型组、氯雷他定组、鼻敏康组。用烟熏法造成肺气虚型大鼠模型,在此基础上,用卵白蛋白(OVA)造成变应性鼻炎大鼠模型。给药1 w后处死大鼠,剥取鼻黏膜,匀浆后离心,检测上清液中TLR2和TLR4含量。结果:与模型组比较,氯雷他定组与鼻敏康组TLR2、TLR4水平降低(P<0.05,P<0.01),差异有统计学意义。结论:鼻敏康颗粒对变应性鼻炎有治疗作用。

Objective： To observe the effects of Biminkang granules on expressions of TLR2 and TLR4 in nasal mucosas of allergic rhinitis rat models with deficiency of lung-qi. Methods：SD rats were randomly divided into four groups：blank group, model group,loratadine group, Biminkang group. Rat models were induced by smoking and intraperitoneal injection of ovalbumin （OVA）. Rats were sacrificed after one week of continuous administration,then nasal mucosas of rats were stripped and the contents of TLR2 and TLR4 were detected. Results：Compared with the model group,contents of TLR2 and TLR4 were decreased in loratadine group and Biminkang group （P〈0.05,P〈0.01）. Conclusion ：Biminkang granules has curative effect on allergic rhinitis rat models with deficiency of lung-qi.