奥氮平对难治性抑郁症的疗效及认知功能的影响

Influence of olanzapine on curative effect of treatment-refractory depression and cognition function

目的观察奥氮平对难治性抑郁症的疗效及认知功能的影响。方法 72例难治性抑郁症患者采用入院顺序分层随机法分为研究组(奥氮平+帕罗西汀)和对照组(帕罗西汀),在治疗前、治疗后4、8、12周末分别用汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评定疗效和副作用,韦氏记忆量表(WMS)评定治疗前后患者认知功能的改变。结果治疗12周后,研究组的WMS的再认、联想及记忆商(MQ)为:(9.9±2.7)分、(10.8±2.5)分、(103.2±12.7)分;对照组分别为(8.9±2.5)分、(8.8±2.4)分、(91.7±12.6)分,两组比较差异有统计学意义(P<0.05)。研究组HAMD评分与治疗前比较明显降低,且显著低于对照组(P<0.05)。治疗后4、8、12周末TESS评分,两组比较差异无统计学意义(P>0.05)。结论奥氮平对难治性抑郁症的疗效确切,安全性高,对认知功能的改善彻底。

Objective To observe the influence of olanzapine on curative effect of treatment-refractory depression and cognition function. Methods According to hospital stratified random sequence, 72 cases of treatment-redfractory depression were randomly divided into study group（olanzapine and paroxetine） and control group（paroxetine）. At the time before treatment and 4 weeks, 8 weeks, and 12 weeks after treatment, Hamilton Depression Scale（HAMD） and Treatment Emergent Symptom Scale（TESS） were used to evaluate curative effects and side effects, and Wechsler Memory Scale（WMS） was used to evaluate change of cognition function. Results 12 weeks after treatment, the WMS recognition, association and memory quotient（MQ） in control group were（9.9±2.7）points,（10.8±2.5）points, and（103.2±12.7）points, and those of study group were（8.9±2.5） points,（8.8±2.4）points, and（91.7±12.6）points. The difference between the two groups was statisitical significant（P〈0.05）. HAMD score of the study group decreased obviously after treatment, and it was lower than that of the control group. The scores of TESS after 4, 8, and 12 weeks of treatment of the two groups were not statistically significant（P〉0.05）. Conclusion Olanzapine is effective in the treatment of treatmene-refractory depression with high safety, and its improvement for cognition function is thoroughly.