高脂血症性急性胰腺炎临床特征及血脂水平与病情轻重的关系

Clinical feature of hyperlipidemic acute pancreatitis and relationship between serum lipid level and severity of hyperlipidemic acute pancreatitis

目的探讨高脂血症性急性胰腺炎的临床特征及血脂水平与病情轻重的关系。方法回顾性分析68例高脂血症性急性胰腺炎(hyperlipidemic acute pancreatitis,HLAP)患者的临床资料,与同期住院的80例胆源性急性胰腺炎(acute biliary pancreatitis,ABP)患者的临床资料作对照。结果 HLAP的甘油三酯及胆固醇水平明显高于ABP,血淀粉酶水平明显低于ABP,HLAP合并糖尿病、脂肪肝的比率及复发率均高于ABP(P<0.05);68例HLAP患者轻症23例,重症45例,甘油三酯水平:轻症:(12.78±7.657)mmol/L,重症:(21.07±11.699)mmol/L(P<0.05);胆固醇酯:轻症:(8.75±4.992)mmol/L,重症:(12.53±6.730)mmol/L(P<0.05)。结论与ABP相比,HLAP多见于年轻患者,易复发,病情较重,易合并基础病;血脂水平的高低与HLAP病情轻重呈正相关。

Objective To investigate the clinical feature of hyperlipidemic acute pancreatitis and the relationship between serum lipid level and severity of hyperlipidemic acute pancreatitis. Methods The clinical data of 68 patients with hyperlipidemic acute pancreatitis（HLAP） and 80 patients with acute biliary pancreatitis（ABP） were retrospectively analyzed and compared. Results The level of triglyceride（TG） and cholesterol ester（CHO） of HLAP were significantly higher than those of ABP. The level of blood amylase in HLAP was lower than ABP. Recurrence incidence and incidence of diabetes and fatty liver of HLAP were higher than ABP（P〈0.05）. Among the 68 cases of HLAP, there were 23 mild cases（MAP） and 45 severe cases（SAP）. The TG level of MAP was（12.78±7.657） mmol/L, and that of SAP was（21.07±11.699） mmol/L（P〈0.05）. The CHO level of MAP was（8.75±4.992） mmol/L, and that of SAP was（12.53±6.730） mmol/L（P〈0.05）. Conclusion Compared with patients with ABP, patients with HLAP are younger, and they are easier to have other diseases. The patients with HLAP are more severe and have a higher recurrence rate. There is a positive correlation between serum lipids and HLAP.