分析比较艾司西酞普兰与帕罗西汀治疗老年性抑郁症患者的临床疗效

Analysis and comparison of curative effect of escitalopram and paroxetine in the treatment of senile depression patients

目的对比分析艾司西酞普兰与帕罗西汀治疗老年性抑郁症患者的临床疗效。方法 130例老年性抑郁症患者随机分为两组,艾司西酞普兰组与帕罗西汀组,每组65例。观察两组治疗效果。结果总的疗效在第8周后差异无统计学意义(P>0.05),但是艾司西酞普兰的起效要快于帕罗西汀,艾司西酞普兰组患者用药后并未出现排尿困难以及震颤的情况,而帕罗西汀组患者出现4例排尿困难,4例震颤。汉密尔顿抑郁量表评分表明8周后艾司西酞普兰组评分为(8.2±2.9)分,而帕罗西汀组评分为(10.1±3.8)分,两组相比,差异有统计学意义(P<0.05)。结论就长期的治疗而言,两者的治疗效果相当。但是短期来看,艾司西酞普兰较帕罗西汀有起效快,副作用小,耐受性好的特点,所以治疗老年性抑郁症,艾司西酞普兰的安全性更高。

Objective To analysis the curative effect of escitalopram and paroxetine in the treatment of senile depression patients. Methods There were 130 cases of senile depression patients randomly divided into two groups as escitalopram group and paroxetine group, and each group contained 65 cases. Results The difference of total curative effect had no statistical significance after 8 weeks（P〉0.05）, Escitalopram works faster than paroxetine. There was no dysuria and tremor in escitalopram group, while there were 4 cases of dysuria and 4 cases of tremor in paroxetine group. Hamilton depression rating scale shows that after 8 weeks the score of escitalopram group was（8.2±2.9） points, while that of paroxetine group was（10.1±3.8） points, and the difference has statistical significance（P〈0.05）. Conclusion In terms of long-term treatment, the curative effects of both groups are similar, but for the short-term treatment, escitalopram, compared with paroxetine, works fast with few side effects and good tolerance. Therefore escitalopram has better safety than paroxetine.