泰山赤灵芝对重复运动后骨骼肌微损伤的保护作用研究

Taishan Ganoderma protective effect of skeletal muscle injury after repeated micro-motion studies

目的探讨泰山赤灵芝对大强度重复运动(力竭运动)后大鼠骨骼肌微损伤的修复及保护作用。方法成年雄性SD大鼠52只,随机分为2组:对照组、实验组。重复运动的动物模型构建:大鼠在跑台上进行下坡跑,速度18 m/min,坡度-16度,大强度重复运动(力竭运动)。设立实验组(喂养泰山赤灵芝水煎液)、对照组,进行同样的重复力竭运动,在同一时间点分别对对照组、实验组在大强度重复运动(力竭运动)后取股四头肌,同时对实验组大鼠进行治疗量泰山赤灵芝喂养,考察该药对大强度重复运动下大鼠骨骼肌微损伤的修复及保护作用,观察对照组、实验组大强度运动(重复运动)下大鼠骨骼肌超微结构变异进行研究。结果补充泰山赤灵芝后重复运动训练下大鼠骨骼肌超微结构变异研究表明:利用透射电镜对补充泰山赤灵芝后大鼠进行相同的大强度重复运动(力竭运动)后,该过程中骨骼肌超微结构变化程度看出大鼠股四头肌的微损伤有显著改善,但是仍表现为肌原纤维排列不规则,肌节不完整,Z线变细,肌丝卷曲等。结论大强度运动下骨骼肌超微结构图谱变异与骨骼肌微损伤或者疲劳存在一定的适应性机制,同时对补充泰山赤灵芝过程中可带来一定的修复机制,泰山赤灵芝对重复运动后骨骼肌超微结构具有保护作用。

Objective：To investigate the effect of the restoration and protection of Taishan Ganoderma after repeated high - intensity exercise（exhaustive exercise）in rat skeletal muscle micro - injury. Methods 52 adult male SD rats were randomly divided into 2 groups：control group,the experimental group. Construction of an animal model of repetitive mo-tion：bench rats ran downhill run,speed 18m/ min,the slope of - 16 degrees,repeated high - intensity exercise（exhaus-tive exercise）. The establishment of the experimental group（ fed Taishan Ganoderma lucidum decoction）,the control group,and the same is repeated exhaustive exercise of the control group,the experimental group were shares after repeated high - intensity exercise（ exhaustive exercise）at the same time point were quadriceps muscle,while the experimental group were treated rats fed the amount of Taishan Ganoderma,restoration and study the protective effect of the drug on rat skeletal micro damage under high - intensity repetitive motion observed in the control group,the experimental group of high- intensity exercise（repetitive movements）Variability in rat skeletal muscle ultrastructure research. Variability of the re-sults of rat skeletal muscle ultrastructure supplement Taishan Ganoderma repeat exercise training studies show that：the use of transmission electron microscopy to complement Taishan Ganoderma same rats after repeated high - intensity exercise （exhaustive exercise）after the process of bone changes seen in rat muscle ultrastructure quadriceps injury significantly im-proved slightly,but still showed myofibrils irregular,incomplete sarcomere,Z line thinning filaments curl. Ultrastructural patterns of variation in skeletal muscle and skeletal muscle damage or fatigue micro - adaptive mechanism under certain conclusions high intensity exercise,while the complementary process of Taishan Ganoderma can bring some repair mecha-nisms,Taishan Ganoderma bone after repetitive motion muscle ultrastructure has a protective effect.