奥美沙坦酯逆转高血压病左室肥厚的疗效观察

The effect of olmesartan medoxomil on the reversal of hypertensive left ventricular in patients with hypertrophy

目的：评价服用奥美沙坦逆转高血压病左室肥厚的疗效。方法选择门诊高血压病伴左室肥厚患者56例，给予奥美沙坦酯片治疗，4周后评价患者左室舒张末期内径（LVDd），舒张期室间隔厚度（IVSd）、左室后壁厚度（LVPWd）及左室重量指数（LVMI）变化，并观察其对患者血尿常规、肝肾功能、血脂、血糖的影响。结果4周后共50例患者收缩压及舒张压均降至正常；治疗后患者 IVSd、LVPWd 及 LVMI 均较治疗前明显下降（ P 〈0.05），而LVDd 无明显变化；治疗后对血尿常规、肝肾功能、血脂、血糖无影响。结论高血压病伴左室肥厚患者每天服用奥美沙坦酯20~40 mg 能有效地逆转左室肥厚。

ObJective：To evaluate the efficacy of taking olmesartan for reversal in patients with essential hypertension. Methods：Hypertension patients with LVH were given olmesartan medoxomil. The left ventricular end diastolic diameter （LVDd）,interventricular septal thickness（IVSd）,left ventricular posterior wall thickness（LVPWd）and left ventricular mass index（LVMI）changes were evaluated after 4 weeks of treatment. The blood and urine routine,hepatic and renal function,blood lipid,blood glucose of patients were also observed. Results：After 4 weeks,the blood pressure of the 50 patients decreased to normal;The IVSd,LVPWd and LVMI were significantly decreased than those before treatment（P 〈0. 05）,while LVDd had no obvious change;The blood and urine routine,blood lipid,blood glucose,liver and kidney function were not changed. Conclusion：Taking olmesartan medoxomil 20 ~ 40 Mg can effectively reverse the left ventricular hypertrophy in patients with left ventricular hypertrophy.