不孕与盆腔炎症性疾病的相关性

Relationship between pelvic inflammatory disease and infertility in female patients

目的探讨盆腔炎性疾病与妇女不孕的相关性。方法选取盆腔炎性疾病(PID)患者352例,按照是否妊娠分为妊娠组和不孕组,并选取我院同期健康体检女性(有生育史)82例作为健康对照组,对其病程、血清内分泌六项等进行分析。结果盆腔炎症性疾病不孕症发生率为44.03%;随着患者病程的延长,其出现不孕症的机会明显增加,差异有统计学意义(P<0.05);与对照组比较,妊娠者和不孕者血清中E2和T的蛋白水平差异无统计学意义(P>0.05),LH和P的蛋白水平明显升高(P<0.05),FSH和PRL的蛋白水平明显降低(P<0.05),妊娠组LH、P、FSH和PRL的蛋白水平均低于不孕组(P<0.05)。结论盆腔炎症性疾病与女性不孕不育密切相关。

Objective To explore the relationship between pelvic inflammatory diseases and infertility in female patients. Methods Totally 352 patients with pelvic inflammatory diseases were selected and divided into two groups according to the pregnancy. And 82 women with childbearing history who received healthy physical examination in the hospital were selected as control group. The dura- tion, serum endocrine examination were compared among three groups. Results The incidence of infertility was 44. 03% in patients with pelvic inflammatory disease, and the rate increased with the enlargement of duration（ P 〈 0.05 ）. There was no statistically signifi- cant difference in serum levels of estradiol and testosterone between control group and pregnancy group, infertility group （P 〉 0. 05）. The serum levels of LH and progesterone in pregnancy group and infertility group were statistically significantly higher than those in control group （ P 〈 0. 05 ）, while the serum levels of FSH and PRL in pregnancy group and infertility group were statistically lower than those in control group （ P 〈 0.05 ）. The serum levels of LH, progesterone, FSH and PRL in pregnancy group were significantly lower than those in infertility group （P 〈 0.05）. Conclusion The results suggest that pelvic inflammatory disease may be closely correlated with female infertility.