摘要
亚砷酸已被广泛用于治疗急性早幼粒细胞白血病(APL),取得了可观的效果。各种砷代谢产物在体内的浓度决定砷剂的疗效和毒性,因此对亚砷酸治疗APL时体内各种砷代谢产物的分析就显得日益重要。近年来人们对各种砷代谢产物的认识不断深入,其检测的方法逐步改进。学者们对使用亚砷酸治疗的APL患者不同阶段的尿液、血液砷代谢产物进行了研究,甚至在脑脊液、唾液中也进行了检测,描绘了亚砷酸治疗APL时各种砷代谢产物在体内的浓度和变化规律。
Arsenic trioxide is widely used in treating human acute promyelocytic leukemia（APL） and have made great achievements.The efficacy and toxicity of arsenic depend on the concentrations of various arsenic metabolites in the body.So it is very important to detect various arsenic metabolites in APL treated with arsenic trioxide.In recent years,people start to know more about arsenic metabolites,and the methods of detectionhave been improved.Some scholars have studied specifics of arsenic metabolites in blood and urine of patients treated with arsenic trioxide at different stages,even in cerebro-spinal fluid and saliva,depicting the concentrations of various arsenic metabolites in the body and changes during the APL treatment.
出处
《医学综述》
2014年第19期3465-3467,共3页
Medical Recapitulate
基金
高等学校博士学科点专项科研基金资助课题(优先发展领域)(20122307130003)
哈医大一院院科研基金博士基金(2013B07)
关键词
亚砷酸
急性早幼粒细胞白血病
砷代谢产物
检测方法
Arsenic trioxide
Acute polymyelocytic leukemia
Arsenic metabolites
Detection method
