多巴胺和去甲肾上腺素治疗感染性休克的研究进展

Research Progress on the Effect of Dopamine and Norepinephrine in Treating Sepsis Shock

感染性休克是感染所致的血流动力学异常,早期血流动力学表现为高排低阻,从而导致外周组织灌注不足及缺氧,如果不能及时逆转,最终导致多器官功能衰竭。感染性休克病死率极高,严重威胁着人类健康。多巴胺与去甲肾上腺均为治疗感染性休克的一线药物。最新研究证实,多巴胺较去甲肾上腺素不良反应更明显,而传统观点认为具有肾脏毒性的去甲肾上腺素不仅具有更好的有效率,而且其对于肾脏、胃肠道、心血管系统、呼吸系统的不良影响并不比多巴胺大。

Septic shock is a kind of abnormal hemodynamics caused by infection,whose early manifestation is high discharge and low resistance,resulting in peripheral tissue hypoperfusion and hypoxia.If not be reversed in time,it will lead to multiple organ failures eventually.The mortality rate of septic shock is extremely high,that it seriously threatens the human health.Dopamine and norepinephrine can both be used as the first-line drugs for septic shock.Recent research indicates the side-effect of dopamine is more obvious than norepinephrine,while the conventional theory indicates norepinephrine could have better effect and less side-effect on kidney,gastrointestinal tract,cardiovascular system,respiratory system than dopamine,despite of its toxicity to kidney.