G蛋白偶联受体与妇科肿瘤

Relationship between G Protein-Coupled Receptor and Gynecological Tumors

G蛋白偶联受体(GPCR)是体内最大的蛋白质亚家族,其介导的信号通路广泛调控体内生理活动,如控制神经、心血管、免疫和内分泌等众系统功能。GPCR可能直接参与肿瘤生长、转移调控。GPCR介导的分子信号可以调控细胞内Wnt信号通路及促分裂素原活化的蛋白激酶(MAPK)信号通路,参与子宫肌瘤、子宫内膜癌、卵巢癌、乳腺癌等肿瘤的生长与转移过程。雌激素、促性腺激素释放激素类似物(GnRHa)、Wnt蛋白等通过与不同的GPCR亚型结合,将胞外信号传递给胞内特异效应器产生生物效应。该文着重介绍GPCR的结构、分类,并就近年来对GPCR的亚型受体信号通路与妇科肿瘤关系予以解读。

The seven-transmembrane G protein-coupled receptor（GPCR）,which belongs to the largest superfamily of signal transduction proteins,plays a crucial role in major biological and pathological processes in neural,cardiovascular,immune and endocrine systems.According to new research,GPCR may be directly involved in the regulation of tumor growth and metastasis.Studies have confirmed that GPCR mediated signal molecules can regulate Wnt signaling pathway and MAPK signal pathway in the cell,involved in the growth and metastasis of uterine fibroids,endometrial cancer,ovarian cancer and breast cancer.Estrogen,GnRHa and Wnt protein combined with different subtypes of GPCR,pass the extracellular signal to specific effectors to produce biological effects.Here introduces the structure,classification and the signaling pathways of GPCR,and summarize the relationship between subtype receptors of GPCR and the progress of the gynecologic tumors.