过敏性紫癜诊疗研究进展

Research Progress on the Treatment for Allergic Purpura

过敏性紫癜(HSP)是以小血管炎为主要病变的系统性血管炎,以非血小板减少性紫癜、关节痛、腹痛、胃肠道出血及肾炎为主要临床表现,大部分患者病程具有自限性,治疗方法较多,尚无统一方案。而紫癜性肾炎是儿科主要的继发性肾小球疾病,肾脏受损是影响HSP预后的最主要因素,治疗不及时易反复和引起并发症,严重者可导致肾衰竭而降低生活质量。尽管此病发病机制仍未完全阐明,但其治疗仍需从多方面着手,故该文对HSP诊疗进展进行综述。

Henoch-Sch（o）nlein purpura（HSP）,also called as allergic purpura,is a kind of systemic vasculitis mainly refers to the small vessel vasculitis,whose clinical manifestations include non-thrombocytopenic purpura,arthronalgia,abdominalgia,gastrointestinal hemorrhage,nephritis,etc.Courses of most patients are self-limited,which leads to multiple treatment methods that cannot be unified.Purpura nephritis is a major secondary glomerular disease commonly seen in department of pediatrics.Kidney damage is the leading factor that affects the prognosis of HSP,without timely treatment,it will easily cause recurrence and incidence of complicaitons,the worst case may have kidney failure and suffer from poorquality of life.Here is to make a review of various diagnosis and treatment methods for HSP,although its pathogenesis still remains unclear.