血清降钙素原及C反应蛋白在鉴别肿瘤患者发热原因中的价值

The value of serum procalcitonin and C-reactive protein in the differentiation of the cause of fever in cancer patients

目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)在鉴别肿瘤患者发热原因中的价值。方法将218例发热患者分为细菌感染组、病毒感染组及肿瘤发热组,检测白细胞计数、中性粒细胞百分率、PCT、CRP阳性率,并进行比较分析。结果细菌感染组白细胞计数、中性粒细胞百分率、PCT、CRP阳性率明显升高,与病毒感染组和肿瘤发热组比较差异有统计学意义(P<0.05);肿瘤发热组PCT阳性率与病毒感染组比较差异有统计学意义(P<0.05)。PCT诊断发热患者细菌感染的敏感度为97.83%,特异性为83.33%,均高于其他指。结论 PCT和CRP检测有助于鉴别肿瘤患者的发热原因,且PCT有更好的特异性及敏感度,为抗感染及肿瘤治疗提供依据。

Objective To evaluate the value of serum procalcitonin（PCT ） and C-reactive protein（CRP） analysis in the differenti-ation of the cause of fever in cancer patients .Methods 218 cases with fever enrolled were divided into three groups ,including bacte-rial infection group ,viral infection group and tumor related fever group .The positive rates of white blood cell（WBC） count ,percent-age of neutrophil ,PCT and CRP were determined and there correlations were analyzed .Results The positive rates of WBC count , percentage of neutrophil ,PCT and CRP in bacterial infection group were significantly increased compared to viral infection group and tumor related fever group（P〈0 .05） .The positive rate of PCT in tumor related fever group was also statistically significant difference compared to viral and bacterial infection group（P〈0 .05） .The sensitivity of PCT was 97 .83% and the specificity of PCT was 83 .33% .Conclusion PCT and CRP can help identify causes of fever in cancer patients .PCT has better sensitivity and specific-ity ,it can help anti-infective and provide experimental evidence for tumor treatment ,and also help determine the disease outcome and clinical deterioration .