HbA1c、CRP、IL-6和IMA对糖尿病肾病早期诊断的价值

The clinical value of HbA1c,CRP,IL-6 and IMA in patients with type 2 diabetes nephropathy

目的探讨糖化血红蛋白(HbA1c)、C反应蛋白(CRP)、白细胞介素6(IL-6)与缺血修饰清蛋白(IMA)对糖尿病肾病早期诊断的价值。方法收集64例2型糖尿病患者的临床资料(单纯2型糖尿病患者34例,糖尿病肾病患者30例),检测各组患者血液中HbA1c、h-CRP、IL-6和IMA水平,另选对照组40例,并进行对比分析。结果单纯2型糖尿病组HbA1c、h-CRP、IL-6和IMA水平均明显高于对照组(P<0.05),糖尿病肾病组HbA1c、h-CRP、IL-6和IMA水平又明显高于单纯2型糖尿病组(P<0.05);HbA1c水平与h-CRP、IL-6、IMA水平呈正相关(P<0.05);HbA1c、h-CRP、IL-6和IMA项联合检测糖尿病肾病的阳性检出率明显高于单项指标(P<0.05)。结论联合检测HbA1c、h-CRP、IL-6和IMA水平有利于糖尿病肾病的早期检出。

Objective To explore the clinical value of glycosylated hemoglobin A1（HbA1c） ,C-reactive protein（CRP） ,interleu-kin-6（IL-6） and ischemia modified albumin（IMA） in patients with type 2 diabetes nephropathy .Methods 64 patients with type 2 diabetes mellitus were divided into simple diabetic mellitus group（34 patients） and diabetic nephropathy group（30 patients） .In ad-dition ,40 healthy subjects were chosen as control group .The levels of HbA1c ,CRP ,IL-6 and IMA were detected .Results The lev-els of HbA1c ,CRP ,IL-6 and IMA in simple diabetic mellitus group were all significantly higher than those in control group（P〈0 .05） .The levels of HbA1c ,CRP ,IL-6 and IMA in diabetic nephropathy group were all significantly higher than those in simple di-abetic mellitus group（P〈0 .05） .There were a positive correlations between the HbA1c level and the levels of CRP ,IL-6 ,IMA（P〈0 .05） .The positive rate of combined detection of HbA1c ,CRP ,IL-6 and IMA was significantly higher than separate index detection （P〈0 .05） .Conclusion The combined detection of HbA1c ,CRP ,IL-6 and IMA may be beneficial to the early diagnosis of diabetic nephropathy ,which will delay the progress of diabetic nephropathy .