川东北地区健康成人糖化血红蛋白水平研究

Reference interval for hemoglobin A1c in healthy adults in northeast Sichuan area

目的：检测川东北地区健康成人的糖化血红蛋白（HbA1c）水平，制订该地区 HbA1c水平的参考区间。方法选取无糖尿病史及其他重大疾病史的494例健康成人为研究对象，检测其静脉血 HbA1c水平，同时进行血常规、血糖、血脂、肝功能、肾功能测定。采用正态分布法的双侧95％可信区间确定参考区间。结果494例健康成人HbA1c水平呈正态分布，参考区间为4．482％～6．012％。不同性别人群HbA1c水平的比较差异无统计学意义（t＝-0．905，P＝0．336）。20～＜35岁人群的 HbA1c水平为（5．109±0．150）％，35～＜65岁人群的 HbA1c水平为（5．224±0．122）％，≥65岁人群的 HbA1c水平为（5．444±0．125）％，不同年龄段人群 HbA1c水平进行两两比较，差异有统计学意义（P＜0．05）。HbA1c水平与年龄呈正相关（r＝0．338， P＜0．01）。结论不同地区有必要建立各自的 HbA1c水平参考区间。

Objective To establish reference interval of hemoglobin A1c（HbA1c） determined in healthy adults in northeast Si-chuan .Methods Venous blood was pumped from 494 individuals without previously diagnosed diabetes and other critical illness . The HbA1c level ,blood routine examination ,blood lipids ,fasting plasma glucose ,liver and kidney function were measured . Reference value of HbA1c was determined by 95% confidence interval through the mean of HbA1c .Results The HbA1c level took on normal distribution in 494 healthy individuals ,and the reference interval was 4 .482% -6 .012% .There was no statistical signifi-cance of HbA1c level between different genders（t= -0 .905 ,P= 0 .366） .The levels of HbA1c in 20 - 〈 35 years old people , 35- 〈65 years old people and ≥65 years old people were（5 .109 ± 0 .150）% ,（5 .224 ± 0 .122）% ,（5 .444 ± 0 .125）% ,and the differences were statistically significant among different age group（P〈0 .05） .The HbA1c level and age were positively correlated （r=0 .338 ,P〈0 .01） .Conclusion It is necessary to establish appropriate reference intervals of HbA1c for different laboratories or areas .