肝硬化中医证型与超声声强定量的相关性研究

The Study of Relationship between the Parameters of Echo Intensity and Traditional Chinese Medicine Syndrome of Hepatic Cirrhosis

目的:探讨不同中医证型肝硬化患者肝脏及脾脏声强值特点及血清纤维化指标之间的相关性,以期为中西医结合诊断肝硬化提供客观依据。方法:对148例肝硬化患者及50例正常对照组进行彩色多普勒超声检查及血清纤维化指标的检测,并根据舌、脉、症对选取的148例肝硬化患者进行中医辨证分型,分析肝硬化各中医证型的声强值特点。结果:不同中医证型肝硬化组患者肝脏、脾脏各区声强值显著高于正常组(P<0.05),肝硬化患者左肝1.5 cm、4.5 cm及右肝1 cm、3 cm、5 cm处声强值与血清HA有相关性,分别为r=512,r=0.470,r=0.543,r=0.568,r=0.497,差异均有统计学意义(P<0.05)。结论:肝脏、脾脏声强值可作为客观、定量诊断肝硬化的指标之一,血清HA水平可作为肝硬化定量诊断的参考指标。肝硬化患者肝脏、脾脏声强值与血清纤维化指标之间有一定的相关性,声强值和血清纤维化指标的联合可为诊断肝硬化提供客观依据。

Objective： To explore ultrasonic echo intensity parameters and serum fibrosis marks of liver and spleen in hep- atic cirrhosis and the relationship between the echo intensity and traditional Chinese medicine syndrome of hepatic cirrhosis, in order to find a new objective basis for hepatic cirrhosis. Methods： The 148 cases patients with cirrhosis and 50 cases people of normal control group were selected for our study and the color doppler ultrasound examination and detection of serum fibrosis index were conducted. The 148 cases patients with cirrhosis were divided according to traditional Chinese medicine and the sound intensity value characteristics were analyzed. Results： The echo intensity of different TCM syndrome in patients with liver cirrhosis group was significantly higher than the normal group （P〈0.05）. The sound intensity values of left liver 1.5 cm, 4.5 cm and right liver 1 cm, 3 cm, 5 cm has correlation with serum HA, respectively, r=512, r-0.470, r=0.543, r=0.568, r=0.497, P〈0.05）. Conclusion： The echo intensity value of liver and the spleen was an objective and quantitative index to diagnose the hepatic cirrhosis. Serum fibrosis marks can be acted as a quantitative diagnosis index for hepatic cirrhosis. There was certain relevance in echo intensity values, serum fibrosis markers and traditional Chinese medicine syndrome of hepatic cirrhosis.