摘要
探讨姜黄素对镉染毒小鼠急性肝脏损伤的保护作用及其可能机制.构建镉致小鼠肝脏损伤模型,同时给予姜黄素保护,通过测定抗氧化酶超氧化歧化酶(SOD)和过氧化氢酶(CAT);氧化损伤指标蛋白羰基化(PCO)、一氧化氮(NO)含量,以及肝脏内微量元素Cd2+、Zn2+和Cu2+的含量,研究镉对肝脏的损伤程度以及姜黄素的保护效果.姜黄素降低肝脏内NO、PCO的含量,缓解SOD、CAT活性降低(p<0.05),减少Zn2+、Cu2+流失.姜黄素通过拮抗镉染毒所致的氧化应激反应,对肝脏的损伤起到保护作用.
Exploring the protection of curcumin on acute liver injury in mice exposed to cadmium and its possible mechanism.Liver injury induced by cadmium in mice was established,given curcumin protection at the same time,through detect the content of antioxidant enzymes superoxide dismutase（SOD）and catalase（CAT）;oxidative damage of protein carbonyl（PCO）,nitric oxide（NO）,and trace elements Cd,Cu and Zn contentin the liver,to research of cadmium on the liver damage degree and the protective effect of curcumin.Curcumin can reduce liver injury caused by cadmium,mainly by reducing the content of NO and PCO（p〈0.05）,respite the activity of SOD、CAT,reducing the cost of Zn^2＋,Cu^2＋.Curcumin though antagonism oxidative stress induce cadmium exposure,have a protective effect on the liver injury.
出处
《陕西科技大学学报（自然科学版）》
2014年第5期129-132,共4页
Journal of Shaanxi University of Science & Technology
基金
陕西省教育厅自然科学基金项目(12JK0712
12JK0623)
西安市未央区科技计划项目(201209)
关键词
姜黄素
镉
肝脏
氧化损伤
curcumin
cadmium
liver
oxidative damage
