醒脑丸对气虚血瘀血管性痴呆大鼠的治疗作用研究

Curative Effect of Xingnao Pills on Rats with Vascular Dementia due to Qi Deficiency and Blood Stasis

目的观察醒脑丸对气虚血瘀血管性痴呆大鼠的治疗作用。方法将气虚造模成功的大鼠随机分为4组,即空白组、模型组、脑复康片组、醒脑丸组。均连续灌胃15 d,每天早晚各1次。观察大鼠行为学指标,测定血浆血栓素B2及大脑皮层一氧化氮(NO)含量;观察大脑海马区病理形态,检测大脑海马促细胞凋亡蛋白Bax表达。结果醒脑丸可降低血浆血栓素B2含量,改善气虚血瘀征象;降低大脑皮层NO含量;对海马CA1区神经元的损伤有明显保护作用;能下调脑缺血后促细胞凋亡蛋白Bax的表达。结论醒脑丸可改善气虚血瘀血管性痴呆大鼠的症状。

Objective To observe the curative effect of Xingnao Pills on rats with vascular dementia due to qi deficiency and blood sta-sis. Methods The successfully constructed rat models of qi deficiency were randomly divided into 4 groups, i. e., blank group, model group, Naofukang Tablet group and Xingnao Pills group. All groups were performed the intragastric infusion for 15 d, once in the morn-ing and once at the night. The praxiology indexes, plasma thromboxane （ TXB2 ） and NO content in the cerebral cortex were detected, the pathomorphology of brain hippocampus was observed and the expression of pro-apoptotic protein Bax in brain hippocampus were detected. Results Xingnao Pills could decrease the level of TXB2, improved the symptoms of qi deficiency and blood stasis;reduced the NO content in the cerebral cortex; had the obvious protective effect on the injury of neurons in the hippocampus CA1 region; could down-regulated the expression of pro-apoptotic protein Bax. Conclusion Xingnao Pills can improve the symptoms of vascular demen-tia rats due to qi deficiency and blood stasis.