脑电双频指数评分用于重症监护病房镇静方案调整的效果

Efficacy of Sedation Scheme Research in ICU by Using Bispectral Index Scores

目的临床药师参与镇静方案研究,使镇静剂更加安全、合理地用于重症监护患者。方法选择18岁以上以治疗为目的进行有创机械通气重症监护病房(ICU)住院患者,利用脑电双频指数(BIS)数值调整其镇静剂,用量使镇静处于最佳水平,记录患者的生命体征、咪达唑仑总用量及平均日用量。结果咪达唑仑平均日用量与年龄呈负相关,与身高、体重、体表面积呈正相关,男性患者用量大于女性患者,60岁以上患者用量小于60岁以下患者。结论咪达唑仑应根据患者的年龄、性别、身高、体重给予个体化镇静。

Objective To make the sedative agents use in ICU patients more safe and more rational by the clinical pharmacists partici-pating in the sedative scheme research. Methods The ICU inpatients aged over 18 years old with injured mechanical ventilation were selected. The bispectral index （ BIS ） was adopted to adjust the sedative agent for making the dosage in the optimal level. The patient vi-tal signs,total amount and average daily dose of midazolam were recorded. Results The average daily dose of midazolam was negatively correlated with age and positively correlated with height,body weight and body surface area. The midazolam dose of the male patients was more than that of the female patients,the midazolam dose for the patients aged over 60 years old was less than that for the pa-tients aged less than 60 years old. Conclusion Midazolam sedation should be individualized according to the patient＇s age,gender, height and weight.