华蟾素注射液腹腔灌注治疗恶性腹水的应用与护理

Application and nursing of Huachansu Injection intraperitoneal perfusion treatment of malignant ascites

目的探讨华蟾素注射液腹腔灌注治疗恶性腹水的护理方法。方法选择浙江省富阳市人民医院2013年1月~2014年1月收治的符合纳入标准的43例患者。留置腹腔引流管,引流腹水1500~2000 mL后给予华蟾素注射液50 mL＋生理盐水50 mL,经引流管缓慢注入腹腔,每周给予药物灌注2~3次,每2周为一疗程。治疗全过程注意监测生命体征,并观察病情,同时给予相应治疗前、治疗中、治疗后的护理。一疗程治疗后根据患者腹水量、腹水肿瘤标志物水平以及体力状况评分（KPS评分）评价疗效。结果 43例患者均完成一疗程的治疗,其中腹水量的有效率为74.4%,腹水肿瘤标志物的有效率为76.7%。治疗后KPS评分与治疗前比较,差异有统计学意义[（61.23±0.98）、（53.23±1.19）分,P〈0.05]。结论华蟾素注射液腹腔灌注治疗恶性腹水可明显减少腹水量,降低腹水中肿瘤标志物水平,并改善体力状况、提高KPS评分。

Objective To explore the nursing methods of Huachansu Injection intraperitoneal perfusion treatment of malignant ascites. Methods 43 patients were chosen who met the inclusion criteria during January 2013 to January2014 in the People＇s Hospital in Fuyang City. They were given the slow perfusion treatment through the drainage tube in abdomen three times a week（50 mL normal saline and 50 mL Huachansu Injection） after draining 1500-2000 mL ascitic fluid with 2-3 times for one week. One therapeutic course was two weeks. It should be paid attention to the vital signs and disease observation in treatment process and gave the nursing care before, in and after treatment in time. Evaluating curative effect was based on the patients′abdominal water volume, ascites tumor marker levels and physical status score（KPS score） after one course of treatment. Results 43 patients all completed one course treatment. The effective rate of the abdominal water volume was 74.4%. The effective rate of ascites tumor markers was 76.7%. To compare the two KPS scores after and before treatment, the differences were statistically significant [（61.23±0.98）,（53.23±1.19） scores, P〈0.05]. Conclusion It can significantly reduce the belly of water, lower levels of tumor markers in the ascites, and improve physical condition and KPS score with Huachansu Injection intraperitoneal perfusion treatment of malignant ascites.