祛银2号膏治疗银屑病(血热证)同身对照临床研究

The Effect of Quyin Ⅱ Plaster Treating Psoriasis of Blood-heat Type:A Parallel Randomized Controlled Trial

目的观察祛银2号膏治疗银屑病(血热证)的临床疗效。方法选取30例门诊银屑病(血热证)患者,采用随机同身对照方法,身体左右侧分别外用祛银2号膏和普连膏,每日2次,治疗4周后观察左右侧皮损消退情况,用银屑病严重程度(PASI)评分及中医证候评分进行评价。结果治疗后祛银2号膏治疗侧和普连膏治疗侧皮损PASI评分、中医证候评分与治疗前相比均有显著降低(P<0.05),组间比较差异无统计学意义(P>0.05)。祛银2号膏和普连膏在PASI临床疗效及中医证候疗效方面,总有效率差异无统计学意义(P>0.05)。结论祛银2号膏可以降低银屑病(血热证)患者PASI评分、改善中医证候积分,不良反应少。

Objective： To explore the effect of Quyin Ⅱ Plaster treating psoriasis of blood-heat type. Methods： In a parallel randomized controlled trial,30 patients of blood-heat type were included. All the participants,who had the bilateral symmetrical lesions,were treated by external with Quyin Ⅱ plaster in the left and Pulian plaster in the right,twice a day for 4 weeks. After treatment,PASI（psoriasis area and severity index） score and TCM syn- drome score were evaluated respectively. Results： Both PASI score and TCM syndrome score decreased signifi- cantly （P〈 0.05） after treatment. The two drugs had no statistically significant difference （P〉 0.05）. In terms of PASI curative effect and TCM syndrome,there were no statistically significant differences in total effective rates of the two drugs （P〉 0.05）. Conclusion： Quyin Ⅱ Plaster can decrease PASI score and TCM syndrome score in psoriasis patients of blood-heat syndrome with little adverse reaction. It may have some effect in treating psoriasis of blood-heat syndrome.