亚低温治疗对心肺复苏后幸存者神经功能和预后的影响

Effects of mild hypothermia treatment on the neurologic function and prognosis of patients after cardiopulmonary resuscitation

目的研究亚低温治疗对心肺复苏后幸存者神经功能和预后的影响。方法 118例心肺复苏幸存患者随机分入实验组和对照组,给予亚低温治疗和常规治疗,统计治疗数据,评价不同治疗方法对患者神经功能和预后效果的影响。结果实验组复苏后第1天、第2天、第4天和第6天的格拉斯哥昏迷指数及综合评分分别为2.31±0.24、3.09±0.32、3.75±0.52、4.62±0.65和3.76±0.45;对照组对应得分分别为0.87±0.13、1.54±0.42、2.46±0.63、2.96±0.58和2.74±0.52。结论亚低温疗法能够有效缓解患者心肺复苏后高灌注造成的二次伤害,促进患者神经功能的恢复,提高患者生活质量。

Objective To investigate the effects of mild hypothermia treatment on the neurologic function and prognosis of patients after cardiopulmonary resuscitation.Methods 118 patients after cardiopulmonary resuscitation were randomly divided into the experimental group （treated with mild therapeutic hypothermia） and control group （treated with conventional therapy ） with the core body temperature reduced and maintained 32℃ to 34℃for 24 hours or normothermia.The neurologic function and prognosis of two groups were compared.Results The Glasgow Coma Scale score was 2.31 ± 0.24 ,3.09 ± 0.32 ,3.75 ± 0.52 , 4.62 ± 0.65 and 3.76 ± 0.45 in the experimental group ,and 0.87 ± 0.13 ,1.54 ± 0.42 ,2.46 ± 0.63 ,2.96 ± 0.58 and 2.74 ± 0.52 in the control group ,respectively.Conclusion The mild therapeutic hypothermia can effectively relieve the high perfusion secondary damage of patients after cardiopulmonary resuscitation and improve the recovery of neurologic function.