吉林省1772株结核分枝杆菌卡那霉素耐药状况分析

Analysis of kanamycin resistance in 1772 mycobacterium tuberculosis of Jilin province

目的完善吉林省结核病耐药谱分析,采用国际通用的比例法获得吉林省结核病卡那霉素耐药资料,评价本省结核治疗临床常用药效果。方法按照国际通用标准,采用100%诊断中心抽样方法,对分离培养阳性菌株进行菌型鉴定及卡那霉素(KM)药物敏感性测试。结果收集到可供分析的结核分枝杆菌分离株1 772株,卡那霉素的耐药率为4.91%;其中来自初治涂阳肺结核患者的菌株为1 175株(66.14%),卡那霉素耐药率为3.74%;来自复治涂阳肺结核患者菌株597株(33.69%),卡那霉素耐药率为7.20%。结论吉林省结核病卡那霉素初、复治耐药率均高于全国平均水平,应加强二线抗结核药物的规范、合理使用。

Objective To surveillance network to improve drug resistance of tuberculosis in Jilin province, apply international comparability of TB resistant to kanamycin information to evaluate the effect of the current TB control strategies. Methods According to WHO / IUATLD standard ,sampling method using 100% of diagnostic centers for culturepositive isolates were separated bacterial type identification and kanamycin （ KM ） drug susceptibility testing. Results 1 772 strains were collected and isolaled for analysis of mycobacterium tuberculosis, kanamycin resistance rate was 4. 91% , of which isolated from the smear positive TB patients the early of 1 175 （66. 14% ）, kanamycin resistance rate of 3.74% ; 597 strains （33.69%） were isolated from retreatment smear - positive tuberculosis patients, kanamycin resistance was 7.20%. Conclusion Tuberculosis resistant to kanamycin of Jilin province is higher than that of national average level. It＇ s suggested to further strengthen the prevention and treatment of drug -resistant TB.