酸枣仁加锌合剂对睡眠剥夺小鼠综合学习记忆能力的影响

Mixture of spina date seed and zinc gluconate for the ability of learning and memory of sleep deprived mice

目的探讨酸枣仁加锌合剂对睡眠剥夺小鼠学习记忆能力的影响。方法在对80只经过筛选获得学习记忆能力的小鼠进行分组。分为空白组、模型组、阳性组、实验组,在酸枣仁加锌合剂灌胃5 d后进行睡眠剥夺,按时间不同每组分为24 h组和36 h组。造模结束后分别对实验鼠进行水迷宫、避暗、跳台检测,观察其已获得的学习记忆能力的变化情况。结果空白组与模型组之间存在统计学意义(P<0.05),模型组与实验组之间存在统计学意义(P<0.05),阳性药物组与模型组之间差异不稳定。结论睡眠剥对机体的学习记忆能力有负面影响;酸枣仁加锌合剂对小鼠睡眠剥夺引起的学习记忆能力下降有所改善,能较好的维持小鼠已获得的学习记忆能力。

Objective To explore the effects of Mixture of Spina Date Seed and Zinc Gluconate for the ability of leaming and memory of sleep deprived （SD） mice. Methods 80 mice that have got the ability of leaming and memory were divided into four groups, including blank group, model group, positive group and experimental group. 5 days later, get rid of sleep that time is 24 hours and 36 hours, of 80 mice after they were gavaged with the mixture. The end of the building, the four groups mice were tested in water maze, avoid dark, diving platform, to observing the changes of the acquired the ability of leaming and memory. Results Compare of blank group and model group, there is the significant difference （ P 〈 0.05）. Compare of model group and experimental group, there is the significant difference （ P 〈 0.05）. But there is no stable difference between the positive group and model group. Conclusion Sleep deprivation has negative effect of learning and memory ability; The mixture of Spina Date Seed and Zinc Glueonate can improve the mice＇s ability of learning and memory, as well as can better maintain the acquired ability of learning and memory of mice.