摘要
主要组织相容性复合体(major histocompatibility complex,MHC)在免疫应答的启动和免疫调控中发挥重要作用。MHC II类四聚体技术是检测CD4+T细胞的直接有效的特异方法,目前已成为研究T细胞免疫应答的重要技术之一。就MHC II类四聚体技术的基本原理及制备,以及在病毒、免疫监控、自身免疫性疾病、肿瘤治疗等研究领域的应用作综述。
MHC genes play important roles in activation and regulation of immune response. MHC II tetramer technology has been developed to directly visualize antigen-specific CD4+T cells efficiently ex vivo, therefore, it becomes one of the main ways to study T-cell immune responses. The purpose of this review is to describe the principles of MHC-peptide tetramer technology and its construction, then to focus on the use of tetramer technology to study virus infection, anti-tumor actionsand autoimmune disease.
出处
《生命科学》
CSCD
2014年第10期1096-1101,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31172304)