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MHC II类四聚体技术研究进展

Progress on the MHC II tetramer technology
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摘要 主要组织相容性复合体(major histocompatibility complex,MHC)在免疫应答的启动和免疫调控中发挥重要作用。MHC II类四聚体技术是检测CD4+T细胞的直接有效的特异方法,目前已成为研究T细胞免疫应答的重要技术之一。就MHC II类四聚体技术的基本原理及制备,以及在病毒、免疫监控、自身免疫性疾病、肿瘤治疗等研究领域的应用作综述。 MHC genes play important roles in activation and regulation of immune response. MHC II tetramer technology has been developed to directly visualize antigen-specific CD4＋T cells efficiently ex vivo, therefore, it becomes one of the main ways to study T-cell immune responses. The purpose of this review is to describe the principles of MHC-peptide tetramer technology and its construction, then to focus on the use of tetramer technology to study virus infection, anti-tumor actionsand autoimmune disease.
作者 李子彬 董宋鹏 杨杰 高凤山 胡薇
机构地区 吉林农业大学生命科学学院 大连大学生命科学与技术学院
出处 《生命科学》 CSCD 2014年第10期1096-1101,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(31172304)
关键词 主要组织相容性复合体 II类分子 免疫 四聚体 major histocompatibility comlex class II immunue tetramer
分类号 Q352 [生物学—遗传学] R372 [医药卫生—病原生物学]
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参考文献28

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二级参考文献42

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生命科学
2014年 第10期

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