痰液降钙素原对慢性阻塞性肺疾病急性加重期的诊断价值

The diagnosis value of Sputum procalcitonin in acute exacerbations of chronic obstructive pulmonary disease

目的探讨痰液降钙素原（PCT）在慢性阻塞性肺疾病急性加重期（AEcOPD）诊断中的价值。方法选择187例AECOPD患者分为感染组和非感染组，测定痰液及血清PCT、C反应蛋白、白细胞，并与20例对照组（COPD稳定期）进行比较。结果感染组痰液及血清PCT水平高于非感染组及对照组，差异有统计学意义（P〈0．05），感染组痰液PCT检测阳性率90．12％（146／162），血清PCT检测阳性率85．19％（138／162），CRP检测阳性率83．95％（136／162），WBC检测阳性率86．42％（140／162），各指标阳性率间差异无统计学意义（P〉o．05）。结论痰液PCT检测亦可作为AEc0PD是否存在感染的辅助诊断指标。

Objective To investigate the diagnostic value of sputum procalcitonin （PCT） in patients with acute exacerbations of chronic obstructive pulmonary disease （AECOPD）. Methods One hundred and eighty seven cases of AECOPD were divided into infection group and non-infected group. Sputum PCT,serum PCT, C-reactive protein （CRP） and white blood cell （WBC） were measured in infection group,non-infected group and control group （20 cases of stable COPD）. Results The sputum PCT level and serum PCT level were higher in infection gruop than in non-infected group and control group, the difference was statistically significant （ P 〈0.05）. There was no difference between the positive rate of sputum PCT （90.12%,146/162）,serum PCT （85.19%,138/162）,CRP （83.95%,136/162） and WBC （86.42% ,140/162） in the infection group （ P 〉0.05）. Conclusions The sputum PCT can also be used as auxiliary diagnosis index of AECOPD induced by infection.