摘要
COPD相关肺动脉高压（PH）的发生发展与肺部组织慢性炎症密切相关，在COPD相关PH的肺血管收缩及重塑中血小板活化因子（PAF）起重要作用。PAF是一种具有广泛生物学活性的内源性磷脂类炎症介质，能够活化血小板及其他炎症细胞。PAF的主要降解酶是血小板活化因子乙酰水解酶（PAF-AH），其通过水解PAF及相关的氧化磷脂在炎症反应中发挥调节作用。本文就PAF、PAF-AH在COPD相关PH中的作用作一综述。
The development of chronic obstructive pulmonary disease （COPD） associated pulmonary hypertension （PH） is correlated closely with inflammation. Piatelet-activating factor （PAF） plays an important role in pulmonary vasoconstriction and rebuilding of COPD associated PH. PAF is a kind of endogenous phospholipids mediums, which has broad biological activity, and could make platelets and other inflammatory ceils active. The major catabolic enzyme of PAF is platelet-activating factor acetyl hydrolase （PAF-AH）. PAF-AH plays an important regulatory role by hydrolyzing PAF and related oxidized phospholipids. In this paper,the role of PAF and PAF-AH in patients with COPD associated PH are reviewed.
出处
《国际呼吸杂志》
2014年第21期1663-1666,共4页
International Journal of Respiration
基金
国家自然科学基金（81160011）
宁夏回族自治区科技攻关项目（宁陕合作）（2012ZYH225）
关键词
血小板活化因子
血小板活化因子乙酰水解酶
慢性阻塞性肺疾病
肺动脉高压
Platelet-activating factorl Platelet-activating factor acetyl hydrolase
Chronicobstructive pulmonary diseases^Pulmonary hypertension
