喷他佐辛在健忘镇痛慢诱导麻醉中对气管插管应激反应的影响

Effects of pentazocine on intubation stress response during slow induction of anesthesia

目的 :探讨喷他佐辛对健忘镇痛慢诱导麻醉气管插管应激反应的影响。方法 :选择ASAⅠ或Ⅱ级、择期全麻腹部手术患者40例,随机分为对照组芬太尼组(F,n=20)、喷他佐辛组(P,n=20)。两组患者均静注咪达唑仑0.03 mg/kg,随后分别静注芬太尼2μg/kg,喷他佐辛0.8 mg/kg。给药5 min后环甲膜穿刺注入1%丁卡因注射液2 m L行喉部表面麻醉,喉麻3 min时在直视下行气管内插管。记录患者T0、T1、T2、T3、T4、T5、T6各时刻的HR(心率)、SBP(收缩压)、DBP(舒张压)、Sp O2(血氧饱和度)、BIS(脑电双频指数);并记录各时刻的镇静程度。结果:两种药物都能有效的抑制穿刺及插管时血压、心率等应激反应,但喷他佐辛组在慢诱导麻醉插管过程中对心血管系统的影响明显优于芬太尼组。结论:0.8 mg/kg喷他佐辛用于健忘镇痛慢诱导麻醉中有效抑制气管插管应激反应且不良反应发生率低。

Objective To investigate the effect of pentazocine combined with midazolam on intubation stress response in slow induction of anesthesia. Mtheods Forty ASAⅠ~Ⅱpatients were divided into two groups. Anesthesia was induced with midazolam 0.03 mg/kg in both groups,and pentazocine 0.8 mg/kg （i.v.） was given in pentazocine group or fentanyl 2 μg/kg （i.v.） in fentanyl group. Five minutes later, 2 mL of 1% decicaine was administered by cricothyroid membrane puncture to facilitate the intubation.The SpO2, circulatory indexes （HR, SBP, DBP, BIS） and sedation level were measured at T0, T1, T2, T3, T4, T5, T6. Results Both pentazocine and fentanyl can inhibit stress responses to tracheal intubation effectively,but pentazocine group is better than fentanyl group on the cardiovascular stability during slow induction of anesthesia. Conclusion Pentazocine 0.8 mg/kg can inhibit stress responses to tracheal intubation effectively with a low incidence of adverse reactions in the slow induction of anesthesia.