龙岗区产前筛查标志物AFP、β-hCG及uE3中位数与出生缺陷的临床意义

Clinical significance of medians of prenatal screening markers- AFP,β- hCG and uncojugated estriol and birth defects in Longgang District

目的:建立深圳市龙岗区血清标志物AFP、β-h CG及u E3的中位数,分析其与出生缺陷的临床意义。方法:采用时间分辨荧光免疫分析仪检测7323例孕中期孕妇血清AFP、β-h CG及u E3浓度建立中位数,分析中位数调整前、后高风险检出率及风险值的差异。结果:AFP、u E3中位数值与软件内嵌值差异有统计学意义(P<0.05),但β-h CG中位数差异无统计学意义(P>0.05);中位数调整前、后高风险检出率和风险值差异无统计学意义(P>0.05)。结论:三联筛查方案中其中位数对出生缺陷风险值的影响要综合分析。

Objective： To establish the medians of serum markers - alpha fetoprotein （ AFP）,β- human chorionic gonadotropin （β-hCG） and uncojugated estriol in Longgang District, analyze the clinical significance of the medians and birth defects. Methods： The concentrations of serum AFP, β- hCG and uncojugated estriol in 7 323 pregnant women during the second trimester of pregnancy were detec- ted by time - resolved fluorescence immunoassay and the medians were established. The detection rates of high risk and the differences of risk values before and after adjusting the medians were analyzed. Results： There were statistically significant differences between the medians of AFP, uncojugated estriol and software embedded values （ P 〈 0.05 ） , but there was no statistically significant difference in the median of β- hCG （ P 〉 0. 05 ） . There was no statistically significant difference in detection rates of high risk and the differences of risk values between before and after adjusting the medians （ P 〉 0. 05 ） . Conclusion ： The effects of medians of AFP, β- hCG and uncojugated estriol on birth defects risk value in triple test should be comprehensively analyzed.