卵泡抑制素3类似物与妊娠期糖尿病相关性研究

Study on correlation between FSTL3 and gestational diabetes mellitus

目的:研究卵泡抑制素3类似物(FSTL3)水平在妊娠期糖尿病发生发展中的作用。方法:被确诊为妊娠期糖尿病(GDM)的82例孕产妇作为病例组,选择同期就诊的未被诊断为GDM的82例孕产妇作为正常组。收集两组孕产妇的基本资料,采用ELISA方法检测FSTL3水平及其他临床检查指标。结果:单因素方差分析结果显示,两组孕产妇之间的年龄、文化程度、糖尿病家族史、高血压家族史、喜爱甜食、口服葡萄糖耐量试验(OGTT)1 h血糖和FSTL3差异有统计学意义(P<0.05);Logistic多因素回归分析显示,年龄、文化程度、糖尿病家族史、喜爱甜食、OGTT 1 h血糖和FSTL3是GDM的独立影响因素,且文化程度与FSTL3是GDM的保护因素,即FSTL3越高患GDM的可能性越小,FSTL3越低患GDM可能性越大。结论:FSTL3对GDM的发生与发展可能起保护作用。

Objective： To research the role of FSTL3 in occurrence and development of gestational diabetes mellitus （GDM） . Methods： A total of 82 pregnant women diagnosed as GDM definitely were selected as case group, 82 pregnant women without GDM during the same period were selected as control group. The basic data in the two groups were collected, ELASA was used to detect FSTL3 levels and other clinical indexes. Results： The results of univariate analysis showed that there were statistically significant differences !n age, educational level, family history of diabetes, family history of hypertension, liking sweet food, one - hour blood glucose level of oral glucose tolerance test （OGTT） and FSTL3 level between the two groups （P 〈 0.05 ） ; the results of logistic regression analysis showed that age, educational level, family history of diabetes, liking sweet food, one - hour blood glucose level of OGTT and FSTL3 level were independent influencing factors of GDM, educational level and FSTL3 were protective factors, the higher FSTL3 level was, the lower the risk of GDM was. Conclusion： FSTL3 may play a protective role in occurrence and development of GDM.