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对放射性直肠炎的中药保留灌肠技术优化研究 被引量:11

A Study on Enema Technology Optimization in the Treatment of Radiation Proctitis
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摘要 目的探讨中药保留灌肠治疗放射性直肠炎最优技术方案(包括给药温度、滴注时间、药量、插管深度)。方法采用正交试验设计方法,将63例放射性直肠炎患者随机分为9组,按照不同的试验条件灌肠给药。疗程均为6周。分别以治疗后中医证候积分、放射损伤疗效评定结果、体力状况评分为效应指标,对正交试验结果进行方差分析,得出中药保留灌肠治疗放射性直肠炎最优技术方案。结果给药温度(39±0.5)℃、滴注时间30 min、药量100 mL、插管深度20 cm为中药保留灌肠最优技术方案。结论本研究所得放射性直肠炎灌肠条件的优化方案合理可行。 Objective To explore the optimal method of treatment for radiation proctitis by keeping coloclysis with traditional Chinese medicine (TCM), including administation temperature, infusion time, dosage and catheter depth. Methods The orthogonal experimental design was adopted. Sixty-three patients with radiation proctitis were randomly divided into 9 groups, and they were under enema for 6 weeks according to different test conditions. TCM syndrome score, radiation injury effect and Karnofsky scores were set as evaluation indexes. An orthogonal design and analysis of variance were conducted for optimization. The best technical schemes for traditional Chinese herb in treating radiation proctitis were obtained. Results The obtained optimum methods are:drug temperature of (39±0.5)℃, infusion time of 30 minutes, dosage of 100 mL, catheter depth of 20 cm. Conclusion The optimal scheme of enema for the treatment of radiation proctitis is reasonable and feasible.
出处 《中国中医药信息杂志》 CAS CSCD 2014年第11期13-16,共4页 Chinese Journal of Information on Traditional Chinese Medicine
关键词 放射性直肠炎 灌肠疗法 正交试验 肠瑞灌肠剂 radiation proctitis enema therapy orthogonal test Changrui Enema
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参考文献4

  • 1中华人民共和国卫生部.GBZ111-2002放射性直肠炎诊断标准[S].北京:中国标准出版社,2002.
  • 2Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer[M]//biacLeodCM, ed. Evaluation of Chemotherapeutic Agents. Nev York: Columbia University Press, 1949:191-205.
  • 3李宜放,王晞星,刘丽坤,汪欣文,刘改萍,王惠媛.肠瑞灌肠剂对放射性直肠炎大鼠IL-1β及NF-κB表达的影响[J].肿瘤研究与临床,2008,20(10):665-668. 被引量:11
  • 4殷磊.护理学基础[M].3版.北京:人民卫生出版社,2003:216

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