外用青黛治疗桥本甲状腺炎疗效及其对甲状腺自身免疫性抗体的影响

Efficacy of Indigo Naturalis Topical Treatment of Hashimoto's Thyroiditis and Its Effects on Serum TGAb and TPOAb

目的：观察外用青黛对桥本甲状腺炎（HT）血清中甲状腺球蛋白抗体（TGAb）、甲状腺过氧化物酶抗体（TPOAb）的影响。方法将65例HT患者随机分为治疗组33例和对照组32例。2组甲状腺功能亢进、甲状腺功能减退者分别予甲巯咪唑片10 mg/d、左旋甲状腺素片25～50μg/d控制甲状腺功能,稳定2周后,治疗组在此基础上于颈前甲状腺投射区域局部外敷青黛治疗,疗程6个月。结果中医临床证候2组均有改善,组间比较差异有统计学意义（P＜0.05,P＜0.01）。治疗组中医证候疗效为81.82%（27/33）,对照组为65.63%（21/32）,2组比较差异有统计学意义（P＜0.01）。治疗组临床疗效总有效率为84.85%（28/33）,对照组为71.88%（23/32）,2组比较差异有统计学意义（P＜0.05）。治疗组治疗后血清 TGAb、TPOAb 水平较治疗前下降（P＜0.05）,2组比较差异有统计学意义（P＜0.01）。结论外用青黛治疗HT可提高疗效,并能有效降低甲状腺自身免疫性抗体指标。

Objective To observe the efficacy of topical indigo naturalis on the serum thyroglobulin antibody （TGAb） and thyroid peroxidase antibody （TPOAb） in Hashimoto＆#39;s thyroiditis （HT）. Methods Sixty-five cases of HT were randomly divided into the treatment group （33 cases） and the control group （32 cases）. Hyperthyroidism patients and hypothyroidism patients in the two groups were treated with methimazole 10 mg/d and levothyrocine 25-50 μg/d to control their thyroid function. Based on the basic treatment, patients in the treatment group were treated with topical indigo naturalis local external application, which lasted for 6 months. Results TCM clinical symptoms were improved in both two groups, with statistical significance between the two groups （P〈0.05, P〈0.01）. The efficacy of TCM clinical symptoms was 81.82% （27/33） in the treatment group and 65.63% （21/32） in the control group, with statistical significance （P〈0.01）. The total effective rate of the treatment group was 84.85% （28/33） and the control group was 71.88%（23/32）, with statistical significance between the two groups （P〈0.05）. Compared with that before treatment, the levels of TGAb and TPOAb were lower in both groups （P〈0.05）, and with statistical significance between the two groups （P〈0.01）. Conclusion Indigo naturalis can improve efficacy of treatment for HT, and effectively reduce autoimmune antibodies indicators of thyroid.