急性白血病早期死亡高危因素分析

The Analyses of risk factor of early death in acute leukemia

目的探讨急性白血病(AL)早期病死的高危因素。方法对我院1998年-20012年收治的165例急性白血病患者分早期死亡和非早期死亡分析研究,对可能引起早期死亡的12项指标进行单因素分析,寻找早期死亡的危险因素。结果肝脏肿大、血红蛋白、皮肤及粘膜出血、骨髓增生极度活跃4项指标P<0.05差异有统计学意义,多器官功能衰竭、体温≥39℃、白细胞计数≥100×109/L、血小板计数≤20×109/L、骨髓白血病细胞≥80%、颅内出血等7个指标,因P<0.01差异有高度统计学意义。结论多器官功能衰竭、白细胞(≥100×109/L)、骨髓白血病细胞(≥80%)、体温(≥39℃)、血小板计数(≤20×109/L)、颅内出血及年龄(≥60岁)等7个指标为急性白血病早期病死的高危因素。

Objective To explore the risk factors of early death in acute leukemia（AL）. Methods To design a survey about risk factors in 165 cases of patients with acute leukemia dividing into early death group and no nearly death group from 1998 to 2012 in our hospital. According to the single factor analysis of 12 indexes of early death, find the significant factors of early death. Results In the single factor analysis, 4 indexes were significant（P〈0.05）, including hepatomegaly, hemoglobin, skin and mucosal bleeding, hyperplasia of marrow hyperactivity. The other indexes including multiple organ failure, the white blood cell count≥100×109/L, the platelet count≤20×109/L, the bone marrow leukemia cells≥80%, temperature≥39℃,intracranial hemorrhage and age（≥60years）, were highly significant（P〈0.01）. Conclusion It is shown that 7 indexes including multiple organ failure, the white blood cell count≥100×109/L, the platelet count≤20×109/L, the bone marrow leukemia cells≥80%, temperature≥39℃,in tracranial hemorrhage, and age（60years）maybe the distinguished risk factor so fearly death in acute leukemia.