武陵地区鼻息肉病家族史调查

The Clinical Survey of Family History on Nasal Polyps in Wuling Region

目的探讨武陵地区鼻息肉与其家族史的关系。方法自行设计调查问卷,采用填写问卷以及电话问卷形式对患者进行调查,对家族性鼻息肉病患者与散发鼻息肉病患者进行比较分析,并对6例家族性鼻息肉病患者的家庭成员发病情况进行调查。结果具有家族史的鼻息肉病患者的首次发病年龄低于散发鼻息肉病患者(P<0.05);复发率高于散发性鼻息肉病患者(P<0.05);家族性鼻息肉病患者与散发鼻息肉病患者变应原检测的比较,两类患者变应原数目和种类分布的差异有统计学意义(P<0.05);家族性鼻息肉病患者I级亲属患病率明显高于II级亲属(P<0.05)。结论家族性鼻息肉病符合多基因遗传的特点,遗传因素在武陵地区鼻息肉病中起重要作用。

Objective To discuss the connection of nasal polyps and family history in Wul ing region.Methods Questionnaires were designed to compare familial nasal polyps patients with spo- radic nasal polyps patients and investigate the incidence of six familial nasal polyps patients.Results The first onset ages of familial nasal polyps patients were younger than those of sporadic nasal polyps patients,The recurrence rate of familial nasal polyps patients is higher than sporadic nasal polyps patients, which were statistically different （ P 〈 0. 05）. There were statistical differences of the amount and species of allergens between familial nasal polyps patients and sporadic nasal polyps patients （P〈0. 05）.The morbidity of first degree relatives was higher than that of second degree relatives in familial nasal polyps patients （P〈0. 05）.Conclusion This study indicated that the genetic model of familial nasal polyps belonged to polygenetics and the genetic factor played an important role in the occurrence of nasal polyps in Wuling region.