降钙素原、C-反应蛋白在革兰阴性菌致病的老年下呼吸道感染疾病中的诊断价值研究

Diagnostic value of procalcitonin and C-reactive protein for gram-negative bacteria-caused lower respiratory tract infection in elderly patients

目的评价降钙素原(PCT)、C-反应蛋白(CRP)联合检测在革兰阴性菌致病的老年下呼吸道感染疾病中的诊断价值。方法回顾分析87例经确诊的下呼吸道感染的老年患者,依据感染类型分成3组,并与健康志愿者对照,比较不同感染类型的患者PCT、CRP水平差异,并利用ROC曲线分析PCT、CRP的诊断价值。结果细菌感染组、非细菌感染组的PCT、CRP水平与对照组比较差异具有统计学意义(P<0.05),其中革兰阴性细菌感染组的PCT水平明显高于革兰阳性细菌感染组,差异具有统计学意义(P<0.01)。绘制革兰阴性组和对照组的ROC曲线,计算出PCT和CRP的曲线下面积分别为0.966、0.928。结论 PCT、CRP检测应用于革兰阴性菌致病的老年下呼吸道感染疾病有明确的诊断价值,且PCT的诊断价值优于CRP。

Objective To evaluate the diagnostic value of procalcitonin（ PCT） and C-reactive protein（ CRP） for lower respiratory tract infections caused by Gram-negative pathogenic bacteria in elderly patients. Methods Retrospective analysis was performed. 87 elderly patients with diagnosed lower respiratory tract infections were divided into three groups according to the type of infection,and compared with healthy volunteers. The PCT and CRP levels in different type of infections were compared; the diagnostic values of PCT and CRP were analyzed by using ROC curves. Results The PCT and CRP levels in both Bacterial infection and non-bacterial infection groups were statistically different from those in control group（ P 〈 0. 05）. The PCT levels in Gram-negative bacterial infection was significantly higher than that in Gram-positive bacterial infection（ P 〈 0. 01）. Areas under the curve of PCT and CRP were 0. 966 and 0. 928 respectively according to the ROC curves of gram-negative group and the control group.Conclusion The PCT and CRP have a definite significance for differential diagnosis of elderly lower respiratory tract infection caused by Gram-negative bacteria,and the diagnostic value of PCT is higher than that of CRP.