硫辛酸对急性脑梗塞病灶密度影和周围水肿带的影响

Impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction

目的 探析硫辛酸对急性脑梗塞患者病灶密度影及周围水肿带的影响.方法 入选我院2012年3月至2014年3月收治的急性脑梗塞患者60例,按照随机单盲原则分为两组,各30例,对照组采用常规治疗,观察组在常规治疗基础上静脉滴注硫辛酸注射液,比较两组临床效果、病灶、周围水肿带面积变化及药物不良反应.结果 观察组治疗有效率为86.7％（26/30）,显著高于对照组的60.0％（18/30）,观察组治疗第7天CT值显著升高,病灶、水肿面积显著减少,而对照组CT值显著降低,病灶、水肿面积显著增加,两组比较差异均具有统计学意义（P＜0.05）.结论 硫辛酸治疗急性脑梗塞疗效确切,有效提高CT值,降低病灶区面积及降低水肿面积,且安全可靠.

Objective To discuss and analyze the impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction （ACI）.Methods 60 patients with ACI in our hospital from March 2012 to March 2014 were chosen and divided into two groups with 30 cases in each group according to random single-blind principle.Control group was treated with routine treatment,while observation group was treated with intravenous drip of lipoic acid injection on the basis of routine treatment.Clinical effect,lesions and surrounding edema area change and adverse drug reaction of two groups were compared.Results The effective rate of observation group was obviously higher than that of control group （86.7% vs.60.0%）.On the 7th day of treatment,CT value of observation group obviously increased,and lesions and edema area obviously decreased; CT value of control group obviously decreased,and lesions and edema area obviously increased; CT value of observation group was obviously higher than that of control group,and lesions and edema area were obviously smaller than those of control group （P 〈 0.05）.Conclusion Lipoic acid has a good curative effect in the treatment of ACI,which can effectively improve CT value,improve relative area without lesion and decrease edema area,so it is safe and reliable.